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Our best seller product #27998 Human α-Klotho Assay Kit - IBL that has been broadly used for research of kidney failure and bone metabolism around the world. We developed #27601 Mouse α-Klotho Assay Kit – IBL in addition to human α-Klotho assay kit. 

“α-klotho” was identified as an extremely down-regulated gene in the genetically-modified mouse of which phenotype is very similar to various symptoms of human aging. Then, the sequences of α-klotho genes have been identified in various species including humans based on the one of mouse. α-Klotho protein is a 130 kDa, one-transmembrane protein and its expression is confirmed in the kidneys and the parathyroid glands. In recent years, it has become clear that α-Klotho is an important molecule within a living organism regulating the metabolism of mineral such as calcium and phosphorus.

Therefore, it is considered that, in α-klotho mouse, early aging-like symptoms are induced by impaired mineral homeostasis caused by decreased expression of α-Klotho. Meanwhile, it is reported that the long N-terminal extracellular domain which comprises the major portion of sequence of α-Klotho protein is released free into blood by shedding. However, there are many unclear points about functions and changes in concentration of free (soluble) α-Klotho protein, so it has been required to develop the measurement system of α-Klotho. 

Liver and Kidney related IBL kits
#27998 Human soluble α-Klotho Assay Kit - IBL
#27601 Mouse soluble α-Klotho Assay Kit - IBL
#27600 Gd-IgA1 (Galactose-deficient IgA1) Assay Kit - IBL
#27362 Human Mac-2 binding protein (Mac-2bp) Assay Kit - IBL
#27996 Human FGF19 Assay Kit - IBL
#27997 Human FGF21 Assay Kit - IBL

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