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Product News2016/11/21
Urine Biomarker for Muscular Dystrophy and Muscle Damage Titin N- Fragment Assay kit - IBL Newly Released!

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201611041920_1.jpg#27900 Titin N- Fragment Assay kit - IBL has been released. Titin (connectin) is a protein that consists of 34,350 amino-acid and specifically expresses in a cross-striated muscle. The molecular weight of human titin is 3,816 kDa and it has been known that as the largest protein among of existing proteins in a living body.

It is one of sarcomere structured protein that is a minimum unit of myofibrillary protein and it has a role as an elastic protein for recovering the length of shortened sarcomere by its contraction.  

It has been known that titin is cleaved by protein metabolic enzymes such as calpain and matrix metalloprotease if muscles are damaged. In fact, it has been confirmed that titin is dramatically cleaved in skeletal muscles of muscular dystrophy patients and various titin fragments are confirmed in blood and urine.  It has been reported that the N fragment (26kDa) and the C fragment (12kDa) are especially increased in urine of muscular dystrophy patients and it is also suggested that it can be a candidate as a non-invasiveness biomarker for monitoring status of muscles. This ELISA kit can measure titin N fragment in human and rat urine.
 

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