IBL News

New scientific articles with regard to the relationship between ANGPTL2 and heart failure have been published.

Angiopoietin-like protein 2 (ANGPTL2), a member of the ANGPTL family, is a secreted glycoprotein that contributes to tissue homeostasis by enhancing tissue remodeling in an autocrine/paracrine manner.

However, overexpressed ANGPTL2 signaling promotes chronic inflammation and subsequent irreversible pathological tissue remodeling and it induces various lifestyle- or aging-associated diseases such as obesity, metabolic syndrome, type 2 diabetes, arteriosclerosis and cancers at the end.

In the following new study it has been reported that circulating ANGPTL2 levels were elevated in heart failure (HF) patients with dilated cardiomyopathy (DCM) and aortic stenosis mouse models.

Circulating ANGPTL2 Levels Increase in Humans and Mice Exhibiting Cardiac Dysfunction. Tian Z et al. Circ J. PMID: 28890470

It has been suggested that the increased ANGPTL2 with HF is mainly observed because of the secretion of ANGPTL2 from cardiomyocyte of heart with stressed dysfunction and it reflects heart dysfunction in HF patients.

Our ELISA product #27745 Human ANGPTL2 Assay Kit – IBL was used for the measurement of serum ANGPTL2 concentration in this study.

In the conclusion of the following new article, excess ANGPTL2 signaling that is induced in the pathologically stressed heart accelerates cardiac dysfunction promotes HF due to decreasing myocardial energy metabolism.

It is also recently reported that the evidence of correlation between elevated circulating ANGPTL2 levels and CVD or HF, and association between ANGPTL2 expression and cellular senescence.

It is also considered that ANGPTL2 autocrine/paracrine signaling is a new factor in accelerating heart disease development in the aging.

In this study, it focus on current topics relevant to ANGPTL2 function in heart disease.

ANGPTL2 autocrine/paracrine signaling is a new factor in accelerating heart disease development in the aging. Here, we focus on current topics relevant to ANGPTL2 function in heart disease.

ANGPTL2 - A New Causal Player in Accelerating Heart Disease Development in the Aging. Oike Y et al. Circ J 2017; 81: 1379-1385 PMID: 28867689


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