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#10391 Anti-Human IDH1 R132S (SMab-1) Mouse IgG MoAb

  • WB
  • Human Glioma (132S mutant)
  • Human Glioma (132S mutant)
Intended Use:
Research reagents
Application:
WB, IHC
Package Size1:
100 μg
Package Size2:
10 μg
Note on Application Abbreviations
WB:Western Blotting
IHC:Immunohistochemistry

※ The product indicated as "Research reagents" in the column Intended Use cannot be used
  for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
  enclosed in the product purchased before use.

Product Overview

Product Overview

Product Code 10391
Product Name Anti-Human IDH1 R132S (SMab-1) Mouse IgG MoAb
Intended Use Research reagents
Application WB, IHC
Species Human
Immunizing antigen Synthetic peptide of a part of human IDH1 R132S
Source Mouse-Mouse hybridoma, ascites
Clone Name SMab-1
Subclass IgG1
Purification Method Affinity purified with Protein A
Specificity React with human IDH1-R132S.
Not react with human IDH1 wild-type or the other IDH1 mutations.
Package Form Lyophilized product from 1 % BSA in PBS containing 0.05 % NaN3
Storage Condition 2 - 8℃
Poisonous and Deleterious Substances Applicable
Cartagena Not Applicable
Package Size 1 100 μg
Package Size 2 10 μg
Remarks1 The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission.

Product Description

Product Description

Specific mutations in the isocitrate dehydrogenase 1 gene IDH1 have been found in several brain tumors including astrocytoma, oligodendroglioma and glioblastoma multiforme, with mutations found in nearly all cases of secondary glioblastomas, but rarely in primary high-grade glioblastoma multiforme. Individuals whose tumor had an IDH1 mutation had longer survival. Another report shows that mutations of IDH2 and IDH1 were found in up to 20 % of cytogenetically normal acute myeloid leukemia (AML). These mutations are known to produce 2-hydroxyglutarate (2HG) from alpha-ketoglutarate, and it is suggested that high 2HG levels may trigger epigenetic changes within the cells and the development of cancer. The IDH1 mutations are remarkably specific to a single codon in the conserved and functionally important Arginine 132 residue (R132) in IDH1. This antibody is developed as a monoclonal antibody which can specifically detect R132S mutation of IDH1.

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