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#11011 Anti- Bcl-1/Cyclin D1 (5D4) Mouse MoAb

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Intended Use：: Research reagents

Application：: WB, IHC

Package Size1：: 200 μg

Note on Application Abbreviations: WB:Western Blotting; IHC:Immunohistochemistry

※ The product indicated as "Research reagents" in the column Intended Use cannot be used
　 for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
　 enclosed in the product purchased before use.

Product Overview

Product Code	11011
Product Name	Anti- Bcl-1/Cyclin D1 (5D4) Mouse MoAb
Intended Use	Research reagents
Application	WB, IHC
Immunizing antigen	recombinant Human PRAD1/cyclin D1 (E. coli)
Source	Mouse-Mouse hybridoma
Clone Name	5D4
Subclass	IgG2a
Purification Method	Affinity Purified with protein A
Specificity	Cross-react with cyclin D2
Package Form	Lyophilized product from 1% BSA in PBS containing 0.05%NaN3
Storage Condition	2 - 8℃
Poisonous and Deleterious Substances	Applicable
Cartagena	Not Applicable
Package Size 1	200 μg
Remarks1	The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission.

Product Description

Bcl-1/Cyclin D1 belongs to the G1 cyclins and plays a key role in cell cycle regulation during the G1/S transition by cooperating with cyclin-dependent kinases (CDKs). Its overexpression may lead to growth advantage for tumor cells by way of cell cycle progression, and actually it has been reported in various human cancers, e.g., esophageal, breast, and bladder carcinomas. Among hematolymphoid malignancies, cyclin D1 overexpression resulting from translocational activation has also been recognized in a subset of B-chronic lymphocytic leukemia (B-CLL), multiple myeloma, splenic marginal zone lymphoma, hairy cell leukemia, and mantle cell lymphoma.