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#11012 Anti- Bcl-1/Cyclin D1 (5D4) Mouse IgG MoAb - Biotin

Intended Use:
Research reagents
Application:
WB, IHC
Package Size1:
100 μg
Note on Application Abbreviations
WB:Western Blotting
IHC:Immunohistochemistry

※ The product indicated as "Research reagents" in the column Intended Use cannot be used
  for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
  enclosed in the product purchased before use.

Product Overview

Product Overview

Product Code 11012
Product Name Anti- Bcl-1/Cyclin D1 (5D4) Mouse IgG MoAb - Biotin
Intended Use Research reagents
Application WB, IHC
Immunizing antigen recombinant Human PRAD1/cyclin D1 (E. coli)
Source Mouse-Mouse hybridoma
Clone Name 5D4
Subclass IgG2a
Purification Method Affinity Purified with protein A
Specificity Cross-react with cyclin D2
Package Form Lyophilized product from 1% BSA in PBS containing 0.05%NaN3
Storage Condition 2 - 8℃
Poisonous and Deleterious Substances Applicable
Cartagena Not Applicable
Package Size 1 100 μg
Remarks1 The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission.

Product Description

Product Description

Bcl-1/Cyclin D1 belongs to the G1 cyclins and plays a key role in cell cycle regulation during the G1/S transition by cooperating with cyclin-dependent kinases (CDKs). Its overexpression may lead to growth advantage for tumor cells by way of cell cycle progression, and actually it has been reported in various human cancers, e.g., esophageal, breast, and bladder carcinomas. Among hematolymphoid malignancies, cyclin D1 overexpression resulting from translocational activation has also been recognized in a subset of B-chronic lymphocytic leukemia (B-CLL), multiple myeloma, splenic marginal zone lymphoma, hairy cell leukemia, and mantle cell lymphoma. Reference: 1. Banno S. et al. Monoclonal antibody against PRAD1/cyclin D1 stains nuclei of tumor cells with translocation or amplification at BCL-1 locus. Jpn. J. Cancer Res. 85, 918-926, 1994. 2. Nakamura S. et al. Immunohistochemical analysis of cyclin D1 protein in hematopoietic neoplasms with special reference to mantle cell lymphoma. Jpn. J. Cancer Res. 85: 1270-1231, 1994. 3. Kurada H. et al. The positive nuclear staining observed with monoclonal antibody against PRAD1/Cyclin D1 correlates with mRNA expression in mantle cell lymphoma. Jpn. J. Cancer Res. 86: 890-898, 1995. 4. Yatabe Y. et al. Clinicopathologic study of PRAD1/cyclin D1 overexpressing lymphoma with special reference mantle cell lymphoma, a distinct molecular pathologic entity. Amer. J. Surg. Pathol. 20: 1110-1122, 1996. 5. Yasogawa Y. et al. The 5D4 antibody (anti-cyclin D1/D2) related antigen: cyotoplasmic staining is correlated to the progression of gastric cancer. Pathology International. 48 (9), 717-722, 1998

FAQ

FAQ

  • Question
    Q.How do you biotinylation the antibody?
  • Answer
    A.NHS-LC-Biotin is used for the biotinylation.

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