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- #11012 Anti- Bcl-1/Cyclin D1 (5D4) Mouse IgG MoAb - Biotin
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#11012 Anti- Bcl-1/Cyclin D1 (5D4) Mouse IgG MoAb - Biotin
- Intended Use:
- Research reagents
- Application:
- WB, IHC
- Package Size1:
- 100 μg
- Note on Application Abbreviations
- WB:Western Blotting
- IHC:Immunohistochemistry
※ The product indicated as "Research reagents" in the column Intended Use cannot be used
for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
enclosed in the product purchased before use.
Product Overview
Product Overview
Product Code | 11012 |
---|---|
Product Name | Anti- Bcl-1/Cyclin D1 (5D4) Mouse IgG MoAb - Biotin |
Intended Use | Research reagents |
Application | WB, IHC |
Immunizing antigen | recombinant Human PRAD1/cyclin D1 (E. coli) |
Source | Mouse-Mouse hybridoma |
Clone Name | 5D4 |
Subclass | IgG2a |
Purification Method | Affinity Purified with protein A |
Specificity | Cross-react with cyclin D2 |
Package Form | Lyophilized product from 1% BSA in PBS containing 0.05%NaN3 |
Storage Condition | 2 - 8℃ |
Poisonous and Deleterious Substances | Applicable |
Cartagena | Not Applicable |
Package Size 1 | 100 μg |
Remarks1 | The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission. |
Product Description
Product Description
Bcl-1/Cyclin D1 belongs to the G1 cyclins and plays a key role in cell cycle regulation during the G1/S transition by cooperating with cyclin-dependent kinases (CDKs). Its overexpression may lead to growth advantage for tumor cells by way of cell cycle progression, and actually it has been reported in various human cancers, e.g., esophageal, breast, and bladder carcinomas. Among hematolymphoid malignancies, cyclin D1 overexpression resulting from translocational activation has also been recognized in a subset of B-chronic lymphocytic leukemia (B-CLL), multiple myeloma, splenic marginal zone lymphoma, hairy cell leukemia, and mantle cell lymphoma. Reference: 1. Banno S. et al. Monoclonal antibody against PRAD1/cyclin D1 stains nuclei of tumor cells with translocation or amplification at BCL-1 locus. Jpn. J. Cancer Res. 85, 918-926, 1994. 2. Nakamura S. et al. Immunohistochemical analysis of cyclin D1 protein in hematopoietic neoplasms with special reference to mantle cell lymphoma. Jpn. J. Cancer Res. 85: 1270-1231, 1994. 3. Kurada H. et al. The positive nuclear staining observed with monoclonal antibody against PRAD1/Cyclin D1 correlates with mRNA expression in mantle cell lymphoma. Jpn. J. Cancer Res. 86: 890-898, 1995. 4. Yatabe Y. et al. Clinicopathologic study of PRAD1/cyclin D1 overexpressing lymphoma with special reference mantle cell lymphoma, a distinct molecular pathologic entity. Amer. J. Surg. Pathol. 20: 1110-1122, 1996. 5. Yasogawa Y. et al. The 5D4 antibody (anti-cyclin D1/D2) related antigen: cyotoplasmic staining is correlated to the progression of gastric cancer. Pathology International. 48 (9), 717-722, 1998
FAQ
FAQ
-
Q.How do you biotinylation the antibody?
-
A.NHS-LC-Biotin is used for the biotinylation.