- HOME >
- For Researchers >
- Product Search >
- Search Result >
- #18101 Anti-Human c-Kit (K963) Rabbit IgG Affinity Purify
Product Search
#18101 Anti-Human c-Kit (K963) Rabbit IgG Affinity Purify
- Intended Use:
- Research reagents
- Application:
- WB, IHC
- Package Size1:
- 100 μg
- Package Size2:
- 10 μg
- Note on Application Abbreviations
- WB:Western Blotting
- IHC:Immunohistochemistry
※ The product indicated as "Research reagents" in the column Intended Use cannot be used
for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
enclosed in the product purchased before use.
Product Overview
Product Overview
Product Code | 18101 |
---|---|
Product Name | Anti-Human c-Kit (K963) Rabbit IgG Affinity Purify |
Intended Use | Research reagents |
Application | WB, IHC |
Species | Human |
Immunizing antigen | Synthetic peptide for the C-terminal of human c-Kit(TASSSQPLLVHDDV) |
Purification Method | Purified with antigen peptide |
Specificity | Human c-Kit (M.W.145 kDa) specific |
Package Form | Lyophilized product from 1 % BSA in PBS containing 0.05 % NaN3 |
Storage Condition | 2 - 8℃ |
Poisonous and Deleterious Substances | Applicable |
Cartagena | Not Applicable |
Package Size 1 | 100 μg |
Package Size 2 | 10 μg |
Remarks1 | The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission. |
Product Description
Product Description
The proto-oncogene c-kit encodes a transmembrane tyrosine kinase receptor, and its ligand for c-Kit receptor has been identified as the stem cell factor (SCF). Recent experimental studies have shown that c-Kit plays a key role in the development of a component of the pacemaker system that is required for generation of autonomic gut motility. These studies further suggest that interaction of the c-Kit and SCF is essential for development of enteric nervous system. Recently, it is reported that the c-Kit may be an important marker for gastrointestinal stromal tumors (GISTs) which may originate from the interstitial cells of Cajal (ICCs).
References
References
- STI571 (Glivec) inhibits the interaction between c-KIT and heat shock protein 90 of the gastrointestinal stromal tumor cell line, GIST-T1. Nakatani H et al. Cancer Sci. 2005 Feb;96(2):116-9.PMID: 15723656
- A c-KIT codon 816 mutation, D816H, in the testicular germ cell tumor: case report of a Japanese patient with bilateral testicular seminomas. Tate G et al. Acta Med Okayama. 2005 Feb;59(1):33-6.PMID: 15902997
Note: Retrieve by PMID number in displayed by abstract: http://www.ncbi.nlm.nih.gov
FAQ
FAQ
-
Q.Can this antibody be used on mice samples ?
-
A.No, it cannot.