- HOME >
- For Researchers >
- Product Search >
- Search Result >
- #29020 Anti-Human MDA5 IgG Affinity Purify
Product Search
#29020 Anti-Human MDA5 IgG Affinity Purify
- Intended Use:
- Research reagents
- Application:
- WB
- Package Size1:
- 100 μg
- Note on Application Abbreviations
- WB:Western Blotting
※ The product indicated as "Research reagents" in the column Intended Use cannot be used
for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
enclosed in the product purchased before use.
Product Overview
Product Overview
Product Code | 29020 |
---|---|
Product Name | Anti-Human MDA5 IgG Affinity Purify |
Intended Use | Research reagents |
Application | WB |
Species | Human |
Immunizing antigen | Synthetic peptide of part of N terminal of human MDA5 (TIEDRNRIAAAENNGN) |
Purification Method | Purified with antigen peptide |
Specificity | Reacts with human and mouse MDA5 |
Package Form | Lyophilized product from 1% BSA in PBS containing 0.05% NaN3 |
Storage Condition | 2 - 8℃ |
Poisonous and Deleterious Substances | Applicable |
Cartagena | Not Applicable |
Package Size 1 | 100 μg |
Remarks1 | The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission. |
Product Description
Product Description
A full-length cDNA encoding MDA5 was isolated by screening a melanoma differentiation-subtracted library and a placenta cDNA library, also known as Ifih1(Interferon induced with helicase C domain protein 1). Yoneyama et al. have identified a DExD/H box-containing RNA helicase, retinoic acid inducible gene I (RIG-I), as an essential component of the sensor of intracellular dsRNA. Furthermore, two other DexD/H-box-containing RNA helicases, MDA5 and LGP2, were found in the mammalian database. MDA5 acts as a positive regulator in the virus-induced activation of type I IFN genes. On the other hand, LGP2 functions as a dominant-negative regulator of RIG-I/MDA5-mediated signaling. These molecules have critical roles for antiviral innate immune responses.
References
References
Note: Retrieve by PMID number in displayed by abstract: http://www.ncbi.nlm.nih.gov