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#27811 Human Total Tau Assay Kit - IBL

  • #27811 Human Total Tau ELISA Kit
  • #27811 Human Total Tau ELISA Kit
  • #27811 Human Total Tau ELISA Kit
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Intended Use:
Research reagents
Measuring Method:
ELISA
Sample Types:
Human
Measuring Samples:
Human CSF
Measurement Range:
12.8 - 817.5 pg/mL
Package Size1:
96 Well

Product Overview

Product Code 27811
Product Name Human Total Tau Assay Kit - IBL
Maker Name Immuno-Biological Laboratories Co., Ltd.
Intended Use Research reagents
Measuring Method ELISA
Conjugate HRP
Species Human
Measuring Samples Human CSF
Measurement Range 12.8 - 817.5 pg/mL
Primary Reaction Overnight at 2 - 8°C
Secondary Reaction 30 minutes at 2 - 8°C
Sensitivity 3.2 pg/mL (Calculated by 2SD methods using the standard.)
Specificity Specifically detect Human Total Tau in human CSF.
Storage Condition 2 - 8°C
Poisonous and Deleterious Substances Not Applicable
Cartagena Not Applicable
Measuring Service Available
Package Size 1 96 Well

Product Description

Tau protein is a 45-50kDa microtubule-associated protein which consists of 352-441 amino acids. It has a role of stabilizing microtubules that transport intracellular substances in nerve cells.
It has been known that tauopathy such as Alzheimer type dementia (AD) and frontotemporal lobar degeneration (FTLD) is developed due to abnormal accumulation of Tau.
3 features of AD, senile plaque, neurofibrillary tangle and neuronal cell death have been observed in the brain of AD patients and it has been considered that neurofibrillary tangle is triggered by abnormal accumulation of Tau.
The main element of neurofibrillary tangle is called PHF (paired helical filament) and it is accumulated in nerve cells.
Overexpressed phosphorylated tau is aggregated and it becomes a main cause of PHF.
It has been thought that GSK-3β is involved in the process of phosphorylation of tau and Aβ promotes the activity for phosphorylation of tau.
It has been observed that the concentration of Tau is very high in CSF of patients with neurodegenerative diseases such as Alzheimer's disease as it is released in CSF due to neuron is destroyed while it is rarely detected in CSF of healthy subjects.
This ELISA can quantitatively measure human total Tau in CSF.

The control set is available for sale on request. Learn More
 

FAQ

  • Question
    Q.Is composition of EIA buffer of each ELISA kit all same? Can it be mixed to use?
  • Answer
    A.No it isn't. As constitute of each EIA buffer is different, it cannot be mixed with other lots or EIA buffers contained in other kind of ELISA kits.
  • Question
    Q.What is the composition of concentrated wash buffer?
  • Answer
    A.It contains ordinary Tween and phosphate buffer (0.05% Tween-20 in PB).
  • Question
    Q.What is the feature of the plate?
  • Answer
    A.We use plate that is flat bottom and removable strip type plate (8wellx 12 strips).
  • Question
    Q.Can I re-use standard after reconstitution?
  • Answer
    A.Not recommended to re-use standard after reconstitution. Please use it at once after the reconstitution.
  • Question
    Q.What is different between reagent blank and test sample blank?
  • Answer
    A.Reagent blank means a well is only added EIA buffer and the purpose is confirming whether the measuring value is influenced by lack of washing process. Test sample blank means a well is added EIA buffer and HRP antibody and the purpose is to calculate the background.
  • Question
    Q.How many samples can be measured by this kit?
  • Answer
    A.The pre-coated plate contained in our ELISA kit is 96 wells plate. We recommend to use 16 wells (2 slits) for standard and 80 wells (10 slits) for 40 samples in duplicate.

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Note: This product is for research use only. It cannot be used as a diagnostic tool or drug.