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#10349F Anti-Human c-Kit (12A8) Mouse IgG MoAb (Frozen)

Intended Use:
Research reagents
Application:
WB, IP, FCM, NT
Package Size1:
100 μg
Note on Application Abbreviations
WB:Western Blotting
IP:Immunoprecipitation
FCM:Flow Cytometry
NT:Neutralization Test

※ The product indicated as "Research reagents" in the column Intended Use cannot be used
  for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
  enclosed in the product purchased before use.

Product Overview

Product Overview

Product Code 10349F
Product Name Anti-Human c-Kit (12A8) Mouse IgG MoAb (Frozen)
Intended Use Research reagents
Application WB, IP, FCM, NT
Species Human
Immunizing antigen Recombinant protein of extracellular domain of human c-Kit
Source Mouse-Mouse hybridoma (X63-Ag8.653×BALB/c spleen cells)
Clone Name 12A8
Subclass IgG1
Purification Method Affinity Purified with protein A
Specificity Confirmed by western blotting with SY cell.
Package Form Frozen product in PBS ( Non-containing BSA and NaN3, sterilized)
Storage Condition ー20℃
Poisonous and Deleterious Substances Not Applicable
Cartagena Not Applicable
Package Size 1 100 μg
Remarks1 The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission.

Product Description

Product Description

The proto-oncogene c-kit encodes a transmembrane tyrosine kinase receptor, and its ligand for c-Kit receptor has been identified as the stem cell factor (SCF). Recent experimental studies have shown that c-Kit plays a key role in the development of a component of the pacemaker system that is required for generation of autonomic gut motility. These studies further suggest that interaction of the c-Kit and SCF is essential for development of enteric nervous system. Recently, it is reported that the c-Kit may be an important marker for gastrointestinal stromal tumors (GISTs) which may originate from the interstitial cells of Cajal (ICCs).

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