Product Search

#28143 Anti- Human Girdin (Phospho-Y1798) Rabbit IgG A.P. (Discontinued : Current stock only)

  • Intestinal tuft cells labeled with phosphorylated Girdin antibody (mouse small intestine). Photo is provided by Dr. Masato Asai, Division Chief of Perinatology, Institute For Developmental Research Aichi Human Service Center.
  • Distribution of phosphorylated Girdin in cultured NIH3T3 cells Photo is provided by Prof. M. Takahashi, Department of Pathology, Nagoya University Graduate School of Medicine
  • Antigenic site and domain structure of Girdin  Photo is provided by Prof. M. Takahashi, Department of Pathology, Nagoya University Graduate School of Medicine
  • Confirming the specificity of anti-phosphorylated Girdin antibody  Photo is provided by Prof. M. Takahashi, Department of Pathology, Nagoya University Graduate School of Medicine
  • pY1798 and Paxillin were colocalized in NIH3T3 cells Photo is provided by Prof. M. Takahashi, Department of Pathology, Nagoya University Graduate School of Medicine
  • Distribution of pY1798 Girdin in mouse brain Photo is provided by Prof. M. Takahashi, Department of Pathology, Nagoya University Graduate School of Medicine
  • Regulatory model of cell migration regulated by Girdin Photo is provided by Prof. M. Takahashi, Department of Pathology, Nagoya University Graduate School of Medicine
Intended Use:
Research reagents
Application:
WB, IHC, ICC
Package Size1:
50 μg
Package Size2:
5 μg
Note on Application Abbreviations
WB:Western Blotting
IHC:Immunohistochemistry
ICC:Immunocytochemistry

※ The product indicated as "Research reagents" in the column Intended Use cannot be used
  for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
  enclosed in the product purchased before use.

Product Overview

Product Overview

Product Code 28143
Product Name Anti- Human Girdin (Phospho-Y1798) Rabbit IgG A.P. (Discontinued : Current stock only)
Maker Name Immuno-Biological Laboratories Co., Ltd.
Intended Use Research reagents
Application WB, IHC, ICC
Species Human, Mouse
Immunizing antigen Synthetic peptide of the phosphorylated part of Human Girdin (KDSNP(pY)ATLPRAS)
Purification Method Affinity purified with antigen peptide
Specificity Cross-react with Human and Mouse Phosphorylated Girdin
Package Form Lyophilized product in PBS containing 1 % BSA and 0.05 % NaN3
Storage Condition 2 - 8℃
Poisonous and Deleterious Substances Applicable
Cartagena Not Applicable
Package Size 1 50 μg
Package Size 2 5 μg
Remarks1 The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission.

Product Description

Product Description

Girdin is a new protein playing an important role in the infiltration and metastasis of cancer cells. A new substance of Akt, Girdin (Girders of actin filament) was discovered by a research group led by Takahashi et al., Nagoya University by screening using yeast two-hybrid method and was elucidated that Girdin has an important role for cell migration downstream of Akt.

It has been proven that Girdin is a new actin binding protein and it restructures actin fibers upon it is phosphorylated by Akt and it involves in forming of lamellipodia that is located at the leading edge of cells and playing an important roles for cell migration by functional analysis. Various antibodies inclusive phosphorylated Girdin antibodies are provided by IBL and it has been suggested that the change of condition of phosphorylated Girdin involves in structure alteration in relation to cell migration in vivo or in vitro by current studies used these antibodies. 

Please refer to the following link.
Use of Anti-phospho-girdin Antibodies to Visualize Intestinal Tuft Cells inFree-Floating Mouse Jejunum Cryosections. Yuka Mizutani et al. Journal of Visualized Experiments.