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#27707 Mouse/Rat Total Insulin CLEIA Kit - IBL

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Intended Use：: Research reagents

Measuring Method：: CLEIA

Sample Types：: Mouse, Rat

Measuring Samples：: EDTA-plasma, Serum

Measurement Range：: 41.15 ～ 30,000 pg/mL　(7 ~ 5,025 pmol/L)

Package Size1：: 96 Well

※ The product indicated as "Research reagents" in the column Intended Use cannot be used
　 for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
　 enclosed in the product purchased before use.

Product Overview

Product Code	27707
Product Name	Mouse/Rat Total Insulin CLEIA Kit - IBL
Maker Name	Immuno-Biological Laboratories Co., Ltd.
Intended Use	Research reagents
Measuring Method	CLEIA
Conjugate	ALP
Species	Mouse, Rat
Measuring Samples	EDTA-plasma, Serum
Measurement Range	41.15 ～ 30,000 pg/mL　(7 ~ 5,025 pmol/L)
Primary Reaction	Overnight at 2 ~ 8°C
Secondary Reaction	120 minutes at room temperature
Storage Condition	2～8°C
Poisonous and Deleterious Substances	Not Applicable
Cartagena	Not Applicable
Measuring Service	Not Available
Package Size 1	96 Well

Product Description

Insulin is peptide hormone that is released from the beta cells of the islets of Langerhans of pancreas.
It is synthesized as 86 amino-acid precursor “proinsulin” and it is cleaved by C-peptide and insulin that consists of 21 amino-acid A-chain and 30 amino-acid β chain that is linked by disulfide binding due to activation of prohormone conversion enzyme (PC2, PC3) in secretory granule.
Insulin deposits glucose and promotes synthesize protein in skeletal muscles. It also has physiological function such as suppress gluconeogenesis in liver and it has been known as an only hormone that can decrease blood glucose.
Insulin is constantly released to maintaining the level of blood glucose while it is also released in large amount stimulated by incretin and glucose for suppressing rapidly increased blood glucose after meal.
However, lack of insulin secretion and decreasing insulin sensitivity are observed and eventually high blood glucose is observed in diabetic conditions.
Measuring insulin in fasting (F-IRI) is required for clinical assessment of diabetes such as function of insulin secretion and insulin resistance.
This CLEIA kit has a wide measurement range to measure the total insulin
(insulin and proinsulin) at low level in fasting and at high level after loading
using only 5 μL sample.

Keywords:
GIP / GLP-1 / Insulin / Incretin