IBL News

Any IBL product & services introduced in this IBL news is applicable for research use only and it cannot be used for diagnosis or medical purpose.

　Our service（LipoSEARCH®）was used in the following paper to analyze cholesterol and triglyceride concentrations across four major classes and 20 subclasses using our GP-HPLC method for detailed lipoprotein profiling.
 
　A research group led by Dr. Yoshinari Uehara, Professor of Faculty of Sports and Health Science, Fukuoka University / Department of Cardiology, Fukuoka University Hospital (Fukuoka, Japan) have demonstrated, for the first time, that policosanol supplementation not only increased the HDL-C levels but also improved the quality of HDL.
 
　Please refer to the original article below for Qualitative improvement of HDL-C by Cuban policosanol.

＜Back ground＞
　Policosanols are long-chain aliphatic alcohols that are found in natural sources, including beeswax, wheat germ, rice bran, and sugarcane. Cuban policosanol supplementation has been reported to increase high-density lipoprotein (HDL)-cholesterol (HDL-C). However, the association between Cuban policosanol supplementation and qualitative alterations in HDL has been unclear.
 
＜Summary＞
　The present study analyzed HDL CEC, HDL-related factors, and HDL subclasses using samples from a previous double-blind, randomized, and placebo-controlled trial that utilized policosanol (Raydel Cuban Policosanol, 20 mg/day) or a placebo that was taken for 12 weeks by healthy Japanese participants. The policosanol group included 15 participants (male = 8, female = 7) whereas the placebo group comprised 17 participants (male = 9, female = 8).
　The results showed that policosanol supplementation induced the elevation of HDL-C and ApoA-I levels and HDL CEC. Particularly, individuals with high HDL-C concentrations at baseline (>64 mg/dL in this study) demonstrated a tendency of upregulation of their HDL capacity via policosanol, and HDL CEC fluctuation were especially associated with HDL-C and ApoA-I changes. Further analysis of HDL subclasses revealed that policosanol induced an increase in cholesterol contents in medium HDL, large HDL, and very large HDL and a decrease in triglycerides contents in small HDL and medium HDL. From the results, improvement in HDL particle functionality and quality through policosanol supplementation was quantitatively demonstrated for the first time.
 
　HDLs have been reported to be associated with human health and longevity in various previous studies. Highｰquality HDLs have anti-inflammatory, anti-glycation, and antioxidant properties and are thought to prevent cardiovascular disease by inhibiting LDLs oxidation and atherosclerosis. The qualitative improvement of HDL cholesterol by the natural ingredient Cuban policosanol in this paper is impactful and noteworthy.
 
＜Cholesterol Uptake Capacity＞
　HDL-C is known to be one of the important indicators in the prevention and management of cardiovascular disease. In recent clinical studies, not only HDL-C but also HDL subclasses, particle numbers, and functional evaluations have attracted growing attentions.
　Cholesterol Efflux Capacity (CEC) of HDL has been used to evaluate HDL function, but it requires complicated processes such as HDL separation by ultracentrifugation, cell culture, labeling with radioisotopes. Recently, it was developed a rapid and simple method for evaluating HDL Cholesterol Uptake Capacity (CUC) using a fully automated immunoassay system (Hl-1000) by Sysmex Corporation. It is now used for evaluation of HDL functionality and we serve as the sales agent for the contracted CUC analysis in Japan.
 
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