IBL News

We have released #27795 Human ANGPTL8 Assay Kit - IBL.

Angiopoietin-like protein 8 (ANGPTL 8) is a protein consists of 198 amino acid that is secreted mainly from liver and fatty tissue.

It has been also known as Betatrophin, Lipasin, refeeding induced fat and liver (RIFL) and TD 26.

It is classified as an atypical ANGPTL family as ANGPTL8 is high homologous with N-terminal domain of ANGPTL3 and ANGPTL4 although it does not have a C-terminal fibrinogen-like domain which is common to ANGPTL family. 

Is has been observed that triglycerides level become lower in plasma sample of ANGPTL8 deficient mice compare to the level in wild type mice after feeding while it has been reported that triglycerides level in plasma sample is elevated only if ANGPTL8 is overexpressed in presence of ANGPTL3.

It has been considered that it becomes a targeted molecule for improving current drug of hyperlipidemia or as a biomarker of metabolic diseases as ANGPTL8 is a lipoprotein regulatory factor that inhibits LPL activity through activation of ANGPTL3.

This ELISA kit can measure full length of ANGPTL8 in human samples.

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