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Product News2019/08/19
Human CD134/OX40 Assay Kit - IBL Newly Released!

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We have released #27110 Human CD134/OX40 Assay Kit - IBL.

CD134/OX40 is a receptor of OX40 ligand (OX40L) transactivated by Tax of HTLV-1. OX40 is expressed in activated CD4+ and CD8+ T cells. OX40 on the activated T cells have a role in proliferation of T cells and production of cytokines by binding with OX40L expressed on antigen presenting cells like dendritic cells or activated B cells. In addition, it also be involved in activated T cell invasion to inflamed area through the binding with OX40L.

It has been observed that soluble CD134 / OX40 in plasma is significantly higher in acute adult T-cell leukemia patients compare to HTLV-1 carriers and healthy individual in recent study. It has also been reported that HTLV-1 gene (number of the copy) in peripheral blood lymphocytes was correlated with soluble OX40 level in plasma of HTLV-1 infected patients. (See reference below)

Tanaka Y, Takahashi Y, Tanaka R, Miyagi T, Saito M, Fukushima T. Association of high levels of plasma OX40 with acute adult T-cell leukemia. Int J Hematol. 2019 Jan 16.

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