IBL News

This newsletter focus about Gd-IgA1 which is a new biomarker of IgA Nephropathy.

Chronic Kidney Disease (CKD) is a progressive loss in kidney function and it affects 1 in 10 people around the world.
Major causes of CKD are type 2 diabetic nephropathy, polycystic kidney disease and chronic glomerulonephritis.
IgA nephropathy (IgAN) is the most common type of primary chronic glomerulonephritis.

Galactose-deficient IgA1 (Gd-IgA1) has been reported as a critical effector molecule in the pathogenesis and progression of IgAN and measuring Gd-IgA1 can replace biopsy.


Gd-IgA1 revel in Serum


Novel ELISA Kit
Specifically detects Gd-IgA1 in Serum, EDTA-Plasma and Urine
The measuring system using snail (helix aspersa ; HAA) lectin has been used in past numerous studies to
detect serum levels of Gd-IgA1 in patients with IgAN . However, instability of glycan-recognizing activity,
development of alternative measuring is desired.

Our ELISA kit (Gd-IgA1 (Galactose-deficient IgA1) Assay Kit: #27600), using monoclonal antibody (KM55)
specifically recognizes galactose-deficient hinge sequence of human Gd-IgA1, is a lectin non-dependent
measuring system that can quantitatively measure Gd-IgA1 in human serum, EDTA-Plasma and urine.

IHC application - Novel antibody (KM55)
Specifically stain IgAN
Monoclonal antibody (Anti-Human Gd-IgA1 (KM55) Rat IgG MoAb: #10777) can detect Gd-IgA 1 in tissue by IHC technique differently from the feature of HAA lectin and it has been revealed that Gd-IgA 1 specifically exists in glomeruli of the patients of IgAN.
IHC Protocol



Proceedings of 16th International Symposium on IgA Nephropathy IgA Nephropathy 2021 
21-23 September 2021 (Virtual)
* IgAN : A South-Asian perspective (Page 5)
* What biomarkers are on the horizon that may help risk stratify patients with IgAN ? (Page 45)
* Clinical significance of intensity of glomerular galactose-deficient IgA1 deposition in IgA nephropathy.
(Page 69)
* Relevance of serum Gd-IgA1 levels in South Asian IgAN-prospective longitudinal cohort (GRACE-IgANI).
(Page 74)

Please feel free to contact us.

Sales Department
Antibody related Business Division
Immuno-Biological Laboratories Co., Ltd.
Email: do-ibl@ibl-japan.co.jp

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