IBL News

Any IBL product introduced in this IBL news is applicable for research use only and it cannot be used for diagnosis or medical purpose.
 
Serum Klotho levels were measured using our ELISA kit in the National Health and Nutrition Examination Survey (NHANES).
 
The National Health and Nutrition Examination Survey (NHANES) is a semi-annual survey conducted by the Centers for Disease Control and Prevention (CDC) to monitor the health and nutritional status of the U.S. population.
On this survey, the CDC selected our ELISA kit below to measure serum Klotho levels in a total of more than 13,000 samples collected between 2007 and 2016.

 
The results of the measurements on Klotho were published in April 2021.
Secondary use of the published data is permitted, and after publication, third-party statistical analyses have been conducted, and as of September 2023, 54 articles have been published.
 
These articles provide statistical analysis of the correlation or association between serum Klotho concentrations and various components of the study subjects, such as disease, mortality, and diets. The following is a list of the subject items (including correlations and associations under limited conditions) for which correlations or associations were found for each study subject for the 54 articles.

 

 

Category	Disease	Correlation or Association Factors	PMID
Disease	Inflammation	Uric acid, CRP, White blood cell, Mean platelet volume (MPV)	35603960
	Cancer	Cancer prevalence, Estradiol concentration, Testosterone concentration	35841322
	Hypertension	Hypertension prevalence (post-menopausal women)	37528365
	Hyperlipidemia	Hyperlipidemia prevalence, Triglyceride concentration	37641103
	Hyperuricemia	Hyperuricemia prevalence (Middle age - Elderly)	36411464
	Osteoporosis	Osteoporosis prevalence (post-menopausal women), Total bone mineral density, Thoracic bone mineral density, Lumbar bone mineral density, Trunk bone mineral density	37452417
			37368163*
	Cardiovascular Disease,  Heart Failure	Congestive heart failure prevalence, Myocardial infarction prevalence, Cardiovascular disease risk factor (BMI, Smoking, Alcohol consumption, Triglyceride, Total cholesterol), ApoB concentration	36351541*
			35795366
			35509269
			36221064
			37352065
	Diabetes	Diabetes prevalence, Glomerular filtration rate: GFR (Type 2 Diabetes), HbA1c (Type 2 Diabetes)	36440221
			35286490
	Arteriosclerosis	Pulse pressure	35189169*
	Abdominal aortic calcification	Abdominal aortic calcification prevalence	35091971*
			35304049*
	Frail	Physical frailty phenotype, Frailty indices	37001558*
	Chronic kidney disease (CKD)	eGFR, Chronic kidney disease prevalence	36276390
	Urinary albumin excretion	Urinary albumin/creatinine ratio	36675565
	Visceral fat	Sagittal abdominal diameter (SAD), Visceral fat accumulation index	36555992
			36814582
	Obesity	Obesity prevalence (Women)	36061981
	Metabolic Syndrome	Metabolic syndrome (MetS) prevalence	35660935*
	Non-alcoholic fatty liver disease (NAFLD)	Non-alcoholic fatty liver disease (NAFLD) severity	37286168
	Anemia	Hemoglobin, Red blood cell, Red blood cell distribution width	36797683
	Depression	Depression prevalence (Women)	37236270
	Cognitive disorder	Consortium to establish a registry for Alzheimer's disease (CERAD), Digit symbol substitution test (DSST)	37560310
			36819720
	Oral Health	Oral health, Periodontitis severity	36204099
			37291590
Mortality	Adult (Age 40-79)	All-cause mortality, Heart disease mortality, Cancer mortality	34628493
	Rheumatoid arthritis	All-cause mortality	37587536
	Hypertension	All-cause mortality	36457804
	Diabetes	All-cause mortality	35738895*
Nutrition	Antioxidant diet	Dietary antioxidant index	36798687
	Anti-inflammatory diet	Dietary inflammatory index (DII)	35761232
			35619959
			37186209*
	Nutrition	Intake of carbohydrate, Alcohol consumption (inverse correlation), Total carbohydrate, Fiber, Niacin	37324910
			37513564
	Diet Pattern	Mediterranean diet	36235560
	Diet Balance	Diet index	37375648
			36712541
Substance Concentration	Testosterone (Men)	Testosterone, Estradiol, Sex hormone binding globulin, Testosterone/Estradiol ratio, Low testosterone, CRP	35820842
			37648906*
	Serum Manganese	Serum manganese	36970731
	Vitamin B12	Vitamin B12	36221417
Toxic Substance,  Environment Pollution	Heavy Metal	Serum lead (Pb)	35753483*
	Polycyclic Aromatic Hydrocarbons	Urinary polycyclic aromatic hydrocarbons	35287592
	PFAS	Serum perfluoroalkyl, Serum polyfluoroalkyl	37228732
	Environment Substance (perchlorate, nitrate, thiocyanate)	Urinary thiocyanate	36096772
	p-Dichlorobenzene	Urinary 2,5-dichlorophenol	36309252*
Other	Sleep	Sleep duration	34955652

Serum Klotho levels have been shown to be associated with as many as 21 diseases.
The association with mortality and blood levels of the substance has also been demonstrated.
Furthermore, it has been shown that diet, exposure to toxic substances/environmental pollution, and sleep may affect serum Klotho levels.
 
Soluble Klotho circulating in the blood is thought to inhibit the development of aging-related diseases by controlling inflammation, oxidative stress, and fibrosis, but the details of its mechanism of action remain unclear and are under active investigation.
In addition, the development of therapies to increase Klotho levels, such as drugs that increase the level of Klotho, protein drugs that administer Klotho itself, and gene therapy, is also underway.
 
We hope that our Klotho-related products will be useful in your research.

Please feel free to contact us.

Sales Department
Antibody related Business Division
Immuno-Biological Laboratories Co., Ltd.
Email: do-ibl@ibl-japan.co.jp



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