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A research group led by Dr. Akio Nakajima: The Jikei University School of Medicine, Nephrology and Hypertension Department, reported the prospective cohort study result about association between serum soluble α-Klotho concentration and cardiovascular disease (CVD) events, fractures, and all-cause mortality in 1,241 adult patients undergoing hemodialysis at 15 domestic facilities.

Patients were divided into quartiles (Q1 – Q4) by soluble α-Klotho levels. In Q1 (< 249 pg/mL), CVD events, fractures, and all-cause mortality were significantly higher, and an increased risk of fracture and all-cause mortality was also observed in Q2 (249-326 pg/mL). These analyses were conducted using Cox hazard regression adjusted for multiple covariates, including age, sex, dialysis history, BMI, albumin, phosphorus, calcium, PTH, FGF23, vitamin D, phosphate binders, and cinacalcet.

■Quartile of serum soluble α-Klotho concentration：
―――――――――――――――
Q1: < 249 pg/mL
Q2: 249–326 pg/mL
Q3: 326–434 pg/mL
Q4: ≥ 434 pg/mL (Control group in this cohort study)
―――――――――――――――

■Risk analysis by each Events
―――――――――――――――
・CVD Event (n = 436)
     Significantly higher CVD risk in Q1 compared to Q4.
     Q1: HR = 1.76 (95% CI: 1.20–2.60)
・Fracture Events (n = 100)
     Significantly higher fracture risk in Q1 and Q2
     Q1: HR = 1.99 (95% CI: 1.01–3.91)
     Q2: HR = 2.04 (95% CI: 1.02–4.07)
・All-cause mortality (n = 228)
     Significantly higher mortality in Q1 and Q2
     Q1: HR = 1.74（95% CI: 1.00–3.03）
     Q2: HR = 1.92（95% CI: 1.11–3.36）
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Soluble α-Klotho is an anti-aging hormone mainly expressed in the kidneys, and regulating diverse physiological functions such as regulating phosphorus metabolism, suppression of oxidative stress, and inhibition of vascular calcification progression.

This study is a large-scale, pioneering report which demonstrating serum soluble α-klotho concentration is independently associated with prognosis in hemodialysis patients, and suggesting that soluble α-klotho may be useful for prognosis and risk stratification.

Please refer to the following publication for more details.
Akio Nakashima et al.
Klotho’s Impact on Cardiovascular Disease, Fractures, and Mortality in Hemodialysis
Kidney International Reports 2025 10;10:3516-3526.

This study used the following IBL ELISA kit to measure soluble α-Klotho.
27998 Human soluble α-Klotho Assay Kit - IBL

We offer a wide range of ELISA kits for lipid metabolism research and also provide testing services.

We hope this information will be useful for your research.
Please feel free to contact us.
 
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Email: do-ibl@ibl-japan.co.jp
 

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