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#18993 Anti-Human Adiponectin Receptor 1 Rabbit IgG Affinity Purify

  • W.B. 18993
Intended Use:
Research reagents
Application:
WB
Package Size1:
100 μg
Package Size2:
10 μg
Note on Application Abbreviations
WB:Western Blotting

※ The product indicated as "Research reagents" in the column Intended Use cannot be used
  for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
  enclosed in the product purchased before use.

Product Overview

Product Overview

Product Code 18993
Product Name Anti-Human Adiponectin Receptor 1 Rabbit IgG Affinity Purify
Intended Use Research reagents
Application WB
Species Human
Immunizing antigen Synthetic peptide of a part of human Adiponectin Receptor 1 (TVELAELGPLLEEKGKRV)
Purification Method Purified with antigen peptide
Specificity Not cross-react with Adiponectin Receptor 2.
Cross-reacts with Mouse
Package Form Lyophilized product from 1 % BSA in PBS containing 0.05% NaN3
Storage Condition 2 - 8℃
Poisonous and Deleterious Substances Applicable
Cartagena Not Applicable
Package Size 1 100 μg
Package Size 2 10 μg
Remarks1 The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission.

Product Description

Product Description

It has been reported that mast cells secrete various bioactive substances (adipokines), in addition to serving as a place for energy storage. Adiponectin has been shown to be one of the adiopkines possessing anti-diabetic, anti-atherosclerotic and anti-inflammatory actions. It was recently shown that the blood adiponectin levels were reduced in cases of obesity. As a result, adiponectin has been attracting close attention as a factor playing a central role in the development of the metabolic syndrome. More recently, adiponectin receptors, Adiponectin Receptor 1 (AdipoR1) and Adiponectin Receptor 2 (AdipoR2) have been identified, inviting very close attention. AdipoR1 is expressed throughout the living body, but its expression is particularly prominent in the skeletal muscles. Unlike the G-protein- coupled receptors (GPCR) reported previously, AdipoR1 can be topologically characterized by an intracellular N-terminal and extracellular C-terminal. Structurally, this receptor seems to belong to a new family of receptors different from the GPCR. AdipoR1 serves as a receptor for globular adiponectin and full-length adiponectin. It has been shown that this receptor transmits signals for suppression of glycogenesis and stimulation of fat burning and sugar utilization through activation of AMP kinase, p36MAPK and PPARα. Measurement of AdipoR1 is expected to be useful in not only diabetes-related research, but also research on inflammation, atherosclerosis and, as has been shown more recently, tumors.