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#28079 Anti-Human Dock7 (Y1118 Phosphorylated) Rabbit IgG Affinity Purify

  • WB
Intended Use：
Research reagents
Application：
WB
Package Size1：
50 μg
Package Size2：
5 μg
Note on Application Abbreviations
WB:Western Blotting

※ The product indicated as "Research reagents" in the column Intended Use cannot be used
　 for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
　 enclosed in the product purchased before use.

Product Overview

Product Overview

Product Code 28079
Product Name Anti-Human Dock7 (Y1118 Phosphorylated) Rabbit IgG Affinity Purify
Intended Use Research reagents
Application WB
Species Human
Immunizing antigen Synthetic peptide of the phosphorylated part of Human Dock7 (ETVPQL(pY)DFTET)
Purification Method Purified with antigen peptide
Specificity Cross-reacts with rat and mouse.
Package Form Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
Storage Condition 2 - 8℃
Poisonous and Deleterious Substances Applicable
Cartagena Not Applicable
Package Size 1 50 μg
Package Size 2 5 μg
Remarks1 The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission.

Product Description

Product Description

Small GTPase of Rho family is one of signaling factors which control alteration of cellular morphology, cell division and differentiation, and plays an important role in regulation of generation and organogenesis at an individual level. Its functions are strictly regulated and its dysfunction causes many diseases such as immunological disease or neurodegenerative disease. Dedicator of cytokinesis (Dock) 7 is a Rho family small GTPase activating factor (or exchange factor) activating Rac1 and Cdc42 specifically of the Rho family small GTPase, and is widely expressed molecule. It is noted that Dock7 is an important factor for proliferation and differentiation of neurocytes or glial cells since it is more expressed especially in both of the central and peripheral nerve tissues. ErbB2 which belongs to the EGF receptor family that is important to neurogenesis interacts with Dock 7 and phosphorylates the 1118th tyrosine of Dock7 directly and activates it. As ErbB2 is a gene responsible for breast cancer, it is also a target of anti-cancer drugs. Dock7 has attracted attention for its relation to breast cancer because it is a novel substrate of ErbB2.
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