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We have released #27265 Human AIM/CD5L Assay Kit - IBL.

AIM (Apoptosis Inhibitor of Macrophage) is produced by macrophages that are one of the type of immune cell, and it is a secreted form of protein that is secreted into blood.　It was named as “AIM” because of the function that suppresses apoptosis by acting on macrophage.[1]　AIM level in serum increases along with obesity and it is taken up by adipose cell.　AIM decomposes triglyceride by suppression of Fatty Acid Synthase (FAS).[2]　This is because it is suggested that AIM associates with various diseases such metabolic syndrome that is originated lifestyle diseases (arteriosclerosis and diabetes) and fatty liver.[3] [4]　In recent studies, it has been reported and suggested that it can be a therapeutic target for acute kidney injuries and liver cancer.[5] [6]　AIM binds to pentamer IgM in blood, but as the antibody used in this kit can detect IgM binding form, Total AIM can be quantitatively measured by this kit.[7]

【Reference】
[1] Miyazaki, Toru, et al. Journal of Experimental Medicine 189.2 (1999): 413-422.
[2] Kurokawa, Jun, et al. Cell metabolism 11.6 (2010): 479-492.
[3] Arai, Satoko, et al. Cell metabolism1.3 (2005): 201-213.
[4] Arai, Satoko, and Toru Miyazaki. Seminars in immunopathology. Vol. 36. No. 1. Springer Berlin Heidelberg, 2014.
[5] Yamazaki, Tomoko, et al. Plos one9.10 (2014): e109123.
[6] Arai, Satoko, et al. Nature medicine 22.2 (2016): 183-193.
[7] Arai, Satoko, et al. Cell reports 3.4 (2013): 1187-1198.

Measurement Range: 0.78 - 50 ng/mL
Required Minimum Sample Volume: 5μL (Recommended dilution ratio Serum, ETDA Plasma : 1,000 fold) 
Measuring Samples: Serum, EDTA-plasma

We also offer testing service using above assay kits by Skylight Biotech. Inc. 
Please contact our testing business team for further details.
 
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