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Product News2019/02/15
Mouse/Rat Intact Proinsulin CLEIA Kit Newly Released!

We have released #27708 Mouse/Rat Intact Proinsulin CLEIA Kit - IBL.

Proinsulin is a precursor of insulin that is synthesized in the β cells of the islet of Langerhans of pancreas.  

Most of the proinsulin synthesized in the rough endoplasmic reticulum of β cells is stored in the secretory granules. It is cleaved by prohormone converting enzyme (PC 2 and PC 3) and it is divided into insulin that consists of 21 amino-acid A chain and 30 amino-acid B chain and C-peptide that consists of 33 amino acid, then it is released in blood by secretory stimulation such as glucose.

However, some proinsulin does not enter secretory granules and it is subsequently  released in blood as intact (full length) proinsulin without the processing. 

It has been known that the ratio of proinsulin and insulin (P/I ratio) is an indicator of dysfunction of pancreatic β cell as the ratio of proinsulin become higher due to abnormality of the processing caused by dysfunction of pancreatic β cell.  

It has been suggested that the P/I ratio is a valuable pancreatic β cell evaluation method that does not require a loading test as it can be measured using blood samples in fasting.  

This CLEIA kit has a wide measurement range to measure the intact proinsulin at low level in fasting and at high level after loading using only 10 μL sample.

Measurement Range: 9 - 6,480 pg/mL (1 - 720 pmol/L)
Required Sample Volume:10 μL
Measuring Samples: Serum, EDTA-plasma and Heparin-plasma

【Related Products】
#27707 Mouse/Rat Total Insulin CLEIA Kit - IBL
#27706 Mouse/Rat Intact Proinsulin Assay Kit - IBL
#27705 Mouse/Rat Total Insulin (high sensitivity) Assay Kit - IBL
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Biomarker of Diabetes Incretin (GLP-1/GIP) Assay Kits
Lifestyle Disease Biomarkers – Testing Services

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