IBL News

Since the products introduced in the following IBL news are research use reagents, they can NOT be used for "diagnosis nor any medical purpose".

ADIPOR1 is essential for vision and its retinal pigment epithelium (RPE) expression is lost in the Mfrp^rd6 mouse.

Valentin M. Sluch et al, at Novartis Institute for Biomedical Research, Cambridge, Massachusetts, United Sates have recently reported in their study with model mice that adiponectin receptor 1 (AdipoR1) is primarily found in the eye and brain with little expression in other tissues, AdiopoR1 KO mice exhibit early visual system abnormalities and are depleted of RHODOPSIN prior to photoreceptor death, and Mfrp^rd6 mouse is lacking AdipoR1 in their retinal pigment epithelium (RPE).

(Reference)
ADIPOR1 is essential for vision and its RPE expression is lost in the Mfrprd6 mouse. Sluch VM et al. Sci Rep. 2018 Sep 25;8(1):14339.

ADIPOR1 and ADIPOR2 are known as receptors to Adiponectin. So far they are well studied its expression in liver or skeletal muscle in relations to insulin resistance. The report is of interest that the study revealed ADIPOR1 is also essential for the functioning of eye.

In this report #18993 Anti-Human Adiponectin Receptor 1 Rabbit IgG Affinity Purify is used with Western Blotting and Immunofluorescence to detect AdioR1 in mice samples. 

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