IBL News

Any IBL product introduced in this IBL news is applicable for research use only and it cannot be used for diagnosis or medical purpose.

Dr. Tomoo Okada, Professor, Department of Nutrition and Life Science, Kanagawa Institute of Technology (Atsugi, Japan) et al. have evaluated the characteristics of chylomicrons (CM) in preterm infants. The subjects consisted of 133 infants (81 boys and 52 girls): 74 were term infants born at 37–41 weeks of gestation and 59 were preterm infants born at 29–36 weeks of gestation. In this study, they analyzed Triglyceride (TG) / cholesterol (C) ratios in CM of cord blood and fasting venous blood (at 1 month of age). 

As a results, it was found that the TG/C ratio in cord blood was significantly lower in preterm infants than in term infants. The TG/C ratio of both preterm and term infants increased over the month, but it was still significantly lower in preterm infants than in term infants. Although preterm infants are able to absorb lipids and secrete CM in utero, the functions of CM lipidation may not be fully developed, and the immaturity remains at 1 month of age. 

This is the first report to analyze the lipid composition of CM in preterm infants, suggesting that impaired CM lipidation in preterm infants is already evident in cord blood.

Please refer to the following publication for more details.
(Article) 
Seimiya A, Okada T et al. Characterization of chylomicron in preterm infants. Pediatr Int. 2019 Jan;61(1):63-66.

In this paper, our evaluation service to classify and quantify lipoproteins by GP-HPLC (LipoSEARCH^®) are used to analyze lipid profile.

Chylomicron (CM)
CM is an exogenous lipoprotein that transports lipids absorbed from the small intestine. CM made in small intestinal epithelial cells is secreted into the lymphatic vessels and enters the macrocirculatory system via the thoracic duct. Once in the macrocirculatory system, CM acquires ApoCs from high-density lipoprotein (HDL), and the TG contained in CM is hydrolyzed by lipoprotein lipase (LPL) to produce free fatty acid (FFA), which serves as an energy source for peripheral cells such as cardiomyocytes, and is also taken up by adipocytes and stored as TG.
CM plays an important role in supplying lipids, which are a dietary source of energy.

We hope that we can support your research.
Please feel free to contact us.

Sales Department
Antibody related Business Division
Immuno-Biological Laboratories Co., Ltd.
Email: do-ibl@ibl-japan.co.jp

IBL-Japan (Specific Antibody Development) 2min video
IBL-Japan (Specific Antibody Development) 30sec video
LipoSEARCH® - Lipoprotein Analyzing Systems (Patented GP-HPLC Systems) 30sec video