IBL News

Any IBL product introduced in this IBL news is applicable for research use only and it cannot be used for diagnosis or medical purpose.

We are pleased to announce that we newly released 27902 Human Titin N-Fragment (Serum) ELISA Kit – IBL

Titin (connectin) is a protein that consists of 34,350 amino-acid and specifically expresses in a cross-striated muscle. The molecular weight of human titin is 3,816 kDa and it has been known that as the largest protein among of existing proteins in a living body. 

It is one of sarcomere structured protein that is a minimum unit of myofibrillary protein and it has a role as an elastic protein for recovering the length of shortened sarcomere by its contraction.  It has been known that titin is cleaved by protein metabolic enzymes such as calpain and matrix metalloprotease if muscles are damaged. 

Actually, massive titin degradation was observed in the skeletal muscle of patients with muscular dystrophy, and the presence of various titin fragments in the blood and urine was confirmed. In particular, it has been reported that the approximately 26 kDa N-fragment on the N-terminal region and the approximately 12 kDa C-fragment on the C-terminal region found in urine are increased in patients with various muscle diseases including muscular dystrophy. 

This kit is a sandwich ELISA with a combination of two antibodies against titin N-fragments. A titin fragment containing N-terminal region in human serum can be measured.

【Releated Products】
27900 Human Titin N-Fragment (Urine) ELISA Kit – IBL
27602 Mouse Titin N-Fragment (Urine) ELISA Kit – IBL

We hope that we can support your research.
Please feel free to contact us.

Sales Department
Antibody related Business Division
Immuno-Biological Laboratories Co., Ltd.
Email: do-ibl@ibl-japan.co.jp


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