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#27602 Mouse Titin N-Fragment (Urine) ELISA Kit - IBL
- Intended Use:
- Research reagents
- Measuring Method:
- ELISA
- Sample Types:
- Mouse, Rat, Others
- Measuring Samples:
- Urine
- Measurement Range:
- 75 - 4,800 pmol/L
- Package Size1:
- 96 Well
※ The product indicated as "Research reagents" in the column Intended Use cannot be used
for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
enclosed in the product purchased before use.
Product Overview
Product Overview
Product Code | 27602 |
---|---|
Product Name | Mouse Titin N-Fragment (Urine) ELISA Kit - IBL |
Maker Name | Immuno-Biological Laboratories Co., Ltd. |
Intended Use | Research reagents |
Measuring Method | ELISA |
Conjugate | HRP |
Species | Mouse, Rat, Others |
Measuring Samples | Urine |
Measurement Range | 75 - 4,800 pmol/L |
Primary Reaction | 60 minutes at 37°C |
Secondary Reaction | 30 minutes at 37℃ |
Sensitivity | 22.8 pmol/L |
Storage Condition | 2~8°C |
Poisonous and Deleterious Substances | Not Applicable |
Cartagena | Not Applicable |
Measuring Service | Available |
Package Size 1 | 96 Well |
Product Description
Product Description
Titin (connectin) is a protein that specifically expresses in a cross-striated muscle and it is known as the largest protein among of existing proteins in a living body.
It is one of sarcomere structured protein that is a minimum unit of myofibrillary protein and it has a role as an elastic protein for recovering the length of shortened sarcomere by its contraction. It has been known that titin is cleaved by protein metabolic enzymes such as calpain and matrix metalloprotease if muscles are damaged.
It has been researched in the field of sports medicine, cardiac disease, NAFLD, sarcopenia and frailty and it is also considered that it can be a candidate as a non-invasive biomarker for monitoring status of muscles. This ELISA kit can measure urine Titin N fragment in mice and various animals such as rat, dog and horse.
Urine Sample Data - Study of Muscle Atrophy in Animal Models - Click here for the pamphlet.
It is one of sarcomere structured protein that is a minimum unit of myofibrillary protein and it has a role as an elastic protein for recovering the length of shortened sarcomere by its contraction. It has been known that titin is cleaved by protein metabolic enzymes such as calpain and matrix metalloprotease if muscles are damaged.
It has been researched in the field of sports medicine, cardiac disease, NAFLD, sarcopenia and frailty and it is also considered that it can be a candidate as a non-invasive biomarker for monitoring status of muscles. This ELISA kit can measure urine Titin N fragment in mice and various animals such as rat, dog and horse.
Urine Sample Data - Study of Muscle Atrophy in Animal Models - Click here for the pamphlet.
References
References
- Urinary titin as an early biomarker of skeletal muscle proteolysis and atrophy in various catabolic conditions. Hyodo M et al. Biochem Biophys Res Commun. 2024 Dec 10;737:150918.PMID: 39488086
- A new immunodeficient Duchenne muscular dystrophy rat model to evaluate engraftment after human cell transplantation. Sato M et al. Front Physiol. 2023 Apr 10;14:1094359.PMID: 37101699
- Urine titin as a novel biomarker for Duchenne muscular dystrophy. Ishii MN et al. Neuromuscul Disord. 2023 Feb 13;33(4):302-308.PMID: 36871413
- A sandwich ELISA kit reveals marked elevation of titin N-terminal fragment levels in the urine of mdx mice. Shirakawa T et al. Animal Model Exp Med
. 2022 Feb;5(1):48-55.PMID: 35229992
Note: Retrieve by PMID number in displayed by abstract: http://www.ncbi.nlm.nih.gov