#10301 Anti-Human ORP150 (Oxygen Regulated Protein, p150) (2F07) Mouse IgG MoAb

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Intended Use：: Research reagents

Application：: WB, IP, IHC

Package Size1：: 100 μg

Package Size2：: 10 μg

Note on Application Abbreviations: WB:Western Blotting; IP:Immunoprecipitation; IHC:Immunohistochemistry

※ The product indicated as "Research reagents" in the column Intended Use cannot be used
　 for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
　 enclosed in the product purchased before use.

Product Overview

Product Code	10301
Product Name	Anti-Human ORP150 (Oxygen Regulated Protein, p150) (2F07) Mouse IgG MoAb
Intended Use	Research reagents
Application	WB, IP, IHC
Species	Human
Immunizing antigen	Recombinant Protein ORP150 (Leu 508 - Leu 999)
Source	Mouse-Mouse hybridoma　(X63-Ag8.653×BALB/c mouse)
Clone Name	2F07
Subclass	IgG2a
Purification Method	Purified with protein A
Specificity	Confirmed with TG and KO mouse
Package Form	Lyophilized product from PBS containing 1 % BSA and 0.05 % NaN3
Storage Condition	2 - 8℃
Poisonous and Deleterious Substances	Applicable
Cartagena	Not Applicable
Package Size 1	100 μg
Package Size 2	10 μg
Remarks1	The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission.

Product Description

Heat shock proteins (HSPs)/stress proteins are molecular chaperones that are induced by various environmental and physiological stimuli. The 150-kDa oxygen-regulated protein (ORP150), a new member of HSP family, functions as a molecular chaperone in the endoplasmic reticulum (1). It is reported that the ORP150 is an integral participant in ischemic cytoprotective pathways. (2). And, the ORP150 is expressed in human wounds along with VEGF. Colocalization of these two molecules was observed in macrophages in the neovasculature, suggesting a role of ORP150 in the promotion of angiogenesis (3). Furthermore, ORP150 is up-regulated in tumors and, in breast tumors, may be associated with tumor invasiveness.