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#10361 Anti-Mouse LEC26 (LA102) Rat IgG MoAb

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Intended Use：: Research reagents

Application：: IHC

Package Size1：: 100 μg

Package Size2：: 10 μg

Note on Application Abbreviations: IHC:Immunohistochemistry

※ The product indicated as "Research reagents" in the column Intended Use cannot be used
　 for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
　 enclosed in the product purchased before use.

Product Overview

Product Code	10361
Product Name	Anti-Mouse LEC26 (LA102) Rat IgG MoAb
Intended Use	Research reagents
Application	IHC
Species	Mouse
Immunizing antigen	Mouse lymphangioma
Source	Rat-Mouse hybridoma　(DA rat lympho node cells × X63 - Ag 8.653, supernatant)
Clone Name	LA102
Subclass	IgG2b, κ
Purification Method	Affinity purified with antigen
Specificity	Reacts to about 26 kDa protein antigen on the lymphatic endothelial membrane of mouse. Not react with blood vascular endothelium, but cross-reacts with some lymphatic cells. Not cross-react with human, rat or guinea pig.
Package Form	Lyophilized product from 1 % BSA in PBS containing 0.05 % NaN3
Storage Condition	2 - 8℃
Poisonous and Deleterious Substances	Applicable
Cartagena	Not Applicable
Package Size 1	100 μg
Package Size 2	10 μg
Remarks1	The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission.

Product Description

Recent years, LYVE-1 (1999, Banerji et al.), podoplanin (1999, Breiteneder-Geleff et al.) and Prox-1 (1999, Wifle & Oliver) were found one after another as specific antigens of lymphatic endothelium and the approach to lymphatic study has progressed dramatically. However, it has been reported that these antigens are not expressed in only lymphatic endothelium according to tissues or clinical conditions, but antibodies against these antigens also react with other vessels especially vascular endothelium. This antibody is generated with an adjuvant-induced benignant lymphangioma by “rapid differential immunization technique” (a more efficient immunization method for antigens which are weak in antigenicity such as one on the lymphatic endothelium.) It is an antibody that is specific to lymphatic vessels but never reacts with vascular endothelium. While, it reacts with some blood cells. Photos are kindly provided by Dr. Taichi Ezaki, Department of Anatomy & Developmental Biology, Tokyo Women's Medical University School of Medicine.