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#18911 Anti-Human Tob (Phosphorylated) Rabbit IgG Affinity Purify
- Intended Use：
- Research reagents
- Application：
- WB, IHC
- Package Size1：
- 100 μg
- Note on Application Abbreviations
- WB:Western Blotting
- IHC:Immunohistochemistry
※ The product indicated as "Research reagents" in the column Intended Use cannot be used
for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
enclosed in the product purchased before use.
Product Overview
Product Overview
| Product Code | 18911 |
|---|---|
| Product Name | Anti-Human Tob (Phosphorylated) Rabbit IgG Affinity Purify |
| Intended Use | Research reagents |
| Application | WB, IHC |
| Species | Human |
| Immunizing antigen | Synthetic peptide of human Tob protein (phosphorylated)(ASSVSS(pS)P(pS)PPFGHS) |
| Purification Method | Purified with antigen peptide |
| Specificity | Confirmed by western blotting using transfectant cells. |
| Package Form | Lyophilized product from 1 % BSA in PBS containing 0.05% NaN3 |
| Storage Condition | 2 - 8℃ |
| Poisonous and Deleterious Substances | Applicable |
| Cartagena | Not Applicable |
| Package Size 1 | 100 μg |
| Remarks1 | The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission. |
Product Description
Product Description
Tob (Transducing molecule of c-ErbB-2) was identified as a molecule that binds to
the receptor tyrosine kinase c-ErbB2 in 1996.
After that, Tob2, BTG1, PC3/TIS21/BTG2, ANA, PC3B etc were found as proteins with a homologous region at about 110 amino acids on the N-terminal side, and are called Tob family proteins.
Tob family proteins are known to suppress cell proliferation when compulsorily expressed in cultured cells.
This proliferative suppression occurs by blocking the expression of cyclin D1.
On the other hand, Tob is rapidly phosphorylated at Ser152, Ser154 and Ser164 by Erk1/2 upon growth-factor stimulation.
It is suggested that this phosphorylation cancels the suppression of cyclin D1 expression.
Thus, it is to thought be Tob and its phosphorylation have important role in the progression from G0 to G1 in the cell cycle.
the receptor tyrosine kinase c-ErbB2 in 1996.
After that, Tob2, BTG1, PC3/TIS21/BTG2, ANA, PC3B etc were found as proteins with a homologous region at about 110 amino acids on the N-terminal side, and are called Tob family proteins.
Tob family proteins are known to suppress cell proliferation when compulsorily expressed in cultured cells.
This proliferative suppression occurs by blocking the expression of cyclin D1.
On the other hand, Tob is rapidly phosphorylated at Ser152, Ser154 and Ser164 by Erk1/2 upon growth-factor stimulation.
It is suggested that this phosphorylation cancels the suppression of cyclin D1 expression.
Thus, it is to thought be Tob and its phosphorylation have important role in the progression from G0 to G1 in the cell cycle.
References
References
Note: Retrieve by PMID number in displayed by abstract: http://www.ncbi.nlm.nih.gov
FAQ
FAQ
-
Q.Can this antibody be used for mice lysate? -
A.The antigen, GST-TobN that is used in the article is fusion protein of N-terminal 168 amino acids of Tob protein and GST.
The sequence of this region is same between human and mouse.
Therefore, theoretically it would be possible to detect using by the antibody #18911 with mice sample but as we have not tested, we cannot be certain about the point.
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