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#28059 Anti-Human XIAP Rabbit IgG Affinity Purify

  • WB
Intended Use：
Research reagents
Application：
WB
Package Size1：
50 μg
Package Size2：
5 μg
Note on Application Abbreviations
WB:Western Blotting

※ The product indicated as "Research reagents" in the column Intended Use cannot be used
　 for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
　 enclosed in the product purchased before use.

Product Overview

Product Overview

Product Code 28059
Product Name Anti-Human XIAP Rabbit IgG Affinity Purify
Intended Use Research reagents
Application WB
Species Human
Immunizing antigen Synthetic peptide of a part of Human XIAP (aa244-263: VSSDRNFPNSTNLPRNPSMA)
Purification Method Purified with antigen peptide
Specificity Cross reacts with mouse.
Package Form Lyophilized product from 1 % BSA in PBS containing 0.05% NaN3
Storage Condition 2 - 8℃
Poisonous and Deleterious Substances Applicable
Cartagena Not Applicable
Package Size 1 50 μg
Package Size 2 5 μg
Remarks1 The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission.

Product Description

Product Description

IAP (inhibitor of apoptosis protein) is an evolutionarily-conserved inhibitory factor of apoptosis. IAP directly binds to caspase which plays the central role in operation of apoptosis and inhibits it. Human XIAP (X-chromosome-linked inhibitor of apoptosis protein) is known as one of the IAP family and binds to caspase-3, 7, and 9 directly and inhibits their functions. XIAP has three BIR (baculovirus IAP repeat) domains. It is confirmed that BIR2 domain binds to caspase-3 and 7, and BIR3 domain binds to caspase-9. Also it has known that the RING finger domain has a ubiquitin ligase activity and is associated with ubiquitination of caspase.
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