#28075 Anti-Mouse LRAT (Lecithin Retinol Acyltransferase) (168) Rabbit IgG Affinity Purify

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Intended Use：: Research reagents

Application：: WB, IHC

Package Size1：: 50 μg

Package Size2：: 5 μg

Note on Application Abbreviations: WB:Western Blotting; IHC:Immunohistochemistry

※ The product indicated as "Research reagents" in the column Intended Use cannot be used
　 for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
　 enclosed in the product purchased before use.

Product Overview

Product Code	28075
Product Name	Anti-Mouse LRAT (Lecithin Retinol Acyltransferase) (168) Rabbit IgG Affinity Purify
Intended Use	Research reagents
Application	WB, IHC
Species	Mouse
Immunizing antigen	Synthetic peptide of a part of Mouse LRAT (168-184) (RYGSRISPQAEKFYDT)
Purification Method	Purified with antigen peptide
Specificity	Cross-reacts with rat.
Package Form	Lyophilized product from 1 % BSA in PBS containing 0.05 % NaN3
Storage Condition	2 - 8℃
Poisonous and Deleterious Substances	Applicable
Cartagena	Not Applicable
Package Size 1	50 μg
Package Size 2	5 μg
Remarks1	The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission.

Product Description

LRAT is a retinol-esterifying enzyme and it is mainly found in G0 stage of stellate cells (Ito cells) in liver. At stellate cells, LRAT is thought to take a role engulfing and pooling excess vitamin A released from hepatocytes. As normal hepatocytes are characterized by lipid droplets pooling esterified vitamin A, LRAT is expected to be a marker of stellate cells in G0 stage. LRAT is also expressed in retinal pigment epithelium, small intestine epithelium and skin keratinocyte as well as liver. The physiological significance of LRAT protein at the endothelium is not clarified, yet. This antibody reacts with stellate cells and endothelia of mouse and rat. WB data is kindly provided by Prof. Haruki Senoo and Dr. Yoshihiro Mezaki of Akita University Faculty of Medicine IHC Arrow (Red); Hepatic stellate cells Arrow (Yellow);Endothelial cells of portal vein ( PV; Portal vein , CV; Central vein ) Bar:　20μm , 10μm (inside) IHC data is kindly provided by Dr. Tomokazu Matsuura and Dr. Keisuke Nagatsuma of Jikei University School of Medicine