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#28137 Anti-Human RIG-I (CTD) Rabbit IgG Affinity Purify

  • WB
  • RIG-I
  • TIAR; marker of stress granule
  • Merge; positive in together
Intended Use:
Research reagents
Application:
WB, ICC
Package Size1:
50 μg
Package Size2:
5 μg
Note on Application Abbreviations
WB:Western Blotting
ICC:Immunocytochemistry

※ The product indicated as "Research reagents" in the column Intended Use cannot be used
  for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
  enclosed in the product purchased before use.

Product Overview

Product Overview

Product Code 28137
Product Name Anti-Human RIG-I (CTD) Rabbit IgG Affinity Purify
Intended Use Research reagents
Application WB, ICC
Species Human
Immunizing antigen Synthetic peptide of CTD domain of human RIG-I (SQEKPKPVPDKENKKLLC)
Purification Method Purified with antigen peptide
Specificity Cross-reacts with mouse.
Package Form Lyophilized product from PBS containing 1 % BSA and 0.05 % NaN3
Storage Condition 2 - 8℃
Poisonous and Deleterious Substances Applicable
Cartagena Not Applicable
Package Size 1 50 μg
Package Size 2 5 μg
Remarks1 The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission.

Product Description

Product Description

RIG-I (retinoic acid inducible gene-I) is one of cytoplasmic viral sencers which has a RNA helicase domain and it is believed to recognize virus-derived double-stranded RNA (dsRNA). It is considered that RIG-I normally exist as inactive form in cytoplasm and turns to active form when it recognizes dsRNA produced as a by-product of viral replication. And it is thought that active form of RIG-I exposes a signaling domain called CARD (caspase recruitment domain) which had been hidden by the steric hindrance and the downstream signaling is activated by interaction of the CARD with IPS-1 expressed on a mitochondria, eventually induces the activation of interferon gene. Thus, RIG-I is believed to play an important role in viral infection-induced signaling. This antibody recognizes CTD (C terminal domain) of RIG-I and is able to detect RIG-I localized in avSGs (antiviral stress granules) that are genesis-induced in virus-infected cells.