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Product News2021/01/14
Elevated urinary Titin after acute stroke related to poor clinical outcomes

Any IBL product introduced in this IBL news is applicable for research use only and it cannot be used for diagnosis or medical purpose.

Nobuto Nakanishi, MD, emergency and critical care medicine, Tokushima University Hospital (Tokushima, Japan) et al. have conducted a study, in which they measured Urinary Titin N-fragment level (day 1, 3, 5, 7) of 41 patients who were admitted to hospital with acute stroke (ischemic stroke, intracerebral hemorrhage, subarachnoid hemorrhage) .

They evaluated the trend of urinary Titin N-fragment level after acute stroke, as well as the association between the peak urinary level and clinical scores of physical, neurological impairment and the degree of care required upon hospital discharge. They reported that urinary Titin N-fragment rapidly increased after stroke and its peak urinary level was associated to poor functional outcomes at hospital discharge.

Elevated Urinary Titin and its Associated Clinical Outcomes after Acute Stroke. Ishihara M et al. J Stroke Cerebrovasc Dis. 2020 Dec 23;30(3):105561 

In patients after stroke it is observed muscle loss in high frequency and the muscle loss lead to impaired physical function and poor clinical outcomes. Titin N-fragment is reported in DMD and subsequently in cardiac disease, liver disease and sports medicine, as it reflects muscle damage in urine. However, urinary Titin N-fragment in acute stroke wasn’t reported so far. 

In this report urinary Titin N-fragment levels are shown to associate to relevant clinical score and index in patients with stroke such as modified Rankin Scale (mRS) score, the National Institutes of Health Stroke Scale (NIHSS) score, and the Barthel index (BI) upon hospital discharge. It is of interest in future that Titin N-fragment can be useful in a study of rehabilitation, the exercise and nutritional intervention after acute stroke. 

For measurement of urinary Titin N fragment level, #27900 Titin N-Fragment Assay Kit - IBL is used in this report.
Note: The kit above is not available in US, but the following antibodies are available for ELISA use.
#10423 Anti-Titin-N (53A1) Mouse IgG MoAb
#10425 Anti-Titin-N (144A2) Mouse IgG MoAb

We hope that we can support your research.
For more information, please feel free to contact us.

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Diagnostic and Research Reagents Division
Immuno-Biological Laboratories Co., Ltd.