IBL News

IBL products introduced in this IBL news are applicable for research use only and cannot be used for diagnostic or medical purposes.
 

　In the Shimane CoHRE Study, Dr. Shozo Yano, associate professor and director of the Nutrition Support Center, Shimane University Hospital, and his research group investigated the skeletal muscle mass (SMI), muscle strength, physical performance, and urinary N-Titin levels in 445 health checkup subjects (mean age: 75.3 ± 8.4 years), including 403 non-sarcopenia, 23 mild sarcopenia, and 19 severe sarcopenia subjects.
　Sarcopenia can be classified into primary sarcopenia, which is caused by aging, and secondary sarcopenia, which has causes other than aging such as disease or malnutrition. Several papers have demonstrated an association between secondary sarcopenia and urinary N-Titin levels, but to our knowledge, this is the first study to examine the association between primary sarcopenia and urinary N-Titin levels.
　As a result of this study, it was reported for the first time that urinary N-Titin levels are an independent determinant of severe sarcopenia and dynapenia, and are useful as a biochemical marker for these conditions.
 
　The median urinary N-Titin levels (interquartile range: IQR) of all 445 subjects were 4.66 (2.91–8.37) pmol/mg Cr, and no difference was observed between men and women. Although urinary N-Titin levels were not significantly correlated with SMI, they were negatively correlated with gait speed significantly (r＝-0.205, p＜0.001) and handgrip strength, albeit at a borderline level (r＝-0.093, p＝0.051).
　As shown below, urinary N-Titin levels (IQR) were significantly higher in the severe group (p ＜ 0.01 vs non-sarcopenia group, p ＜ 0.05 vs mild group) when compared according to sarcopenia severity. 　The 93 subjects diagnosed with dynapenia among the 403 non-sarcopenia subjects also showed significantly higher urinary N-Titin levels than the 310 non-dynapenia subjects (p ＜ 0.001). 　The report concludes that early detection of severe sarcopenia and dynapenia based on urinary N-Titin levels is expected to lead to proactive interventions such as early rehabilitation and nutritional support.
 
　Please refer to the following publication for more details.  
The following IBL ELISA Kit was used in this scientific paper.
・27900 Human Titin N-Fragment (Urine) ELISA Kit - IBL
 
【N-Titin 関連製品】
ELISA Kits
・27902 Human Titin N-Fragment (Serum) ELISA Kit - IBL
・27604 Mouse Titin N-Fragment (Serum) ELISA Kit - IBL
・27602 Mouse Titin N-Fragment (Urine) ELISA Kit - IBL
Antibodies
・10425 Anti-Titin-N (144A2) Mouse IgG MoAb
・10423 Anti-Titin-N (53A1) Mouse IgG MoAb
 
■ Shimane CoHRE Study (Shimane Cohort Study)
　A long-term health study conducted by Center for Community-based Healthcare Research and Education of Shimane University.
■ Sarcopenia
　This refers to a condition of reduced muscle mass and muscle weakness that occurs mainly due to aging. This condition makes it difficult to carry out basic activities of daily living and affects the health of the individual, such as increasing the risk of falling.
■ Dynapenia
　This refers to age-related muscle weakness. Unlike sarcopenia, this condition is not accompanied by a decrease in muscle mass, but only a decrease in muscle weakness.
 
We hope you will find our products useful in your research activities.
 
Keywords: N-titin, Titin, Sarcopenia, Dynapenia, Shimane CoHRE Study
 
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Email: do-ibl@ibl-japan.co.jp
 

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