#10078 Anti-Rat Hepatic Sinusoidal Endothelial Cells (SE-1) Mouse IgG MoAb

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Intended Use：: Research reagents

Application：: WB, IHC

Package Size1：: 100 μg

Package Size2：: 10 μg

Note on Application Abbreviations: WB:Western Blotting; IHC:Immunohistochemistry

※ The product indicated as "Research reagents" in the column Intended Use cannot be used
　 for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
　 enclosed in the product purchased before use.

Product Overview

Product Code	10078
Product Name	Anti-Rat Hepatic Sinusoidal Endothelial Cells (SE-1) Mouse IgG MoAb
Intended Use	Research reagents
Application	WB, IHC
Species	Rat
Immunizing antigen	Rat Hepatic Sinusoidal Endothelial Cells
Source	Mouse-Mouse hybridoma　(X63 - Ag 8.653 × BALB/c mouse spleen cells)
Clone Name	SE-1
Subclass	IgG2a
Purification Method	Affinity purified with Protein A
Package Form	Lyophilized product from 1% BSA in PBS containing 0.05% NaN3.
Storage Condition	2 - 8℃
Poisonous and Deleterious Substances	Applicable
Cartagena	Not Applicable
Package Size 1	100 μg
Package Size 2	10 μg
Remarks1	The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission.

Product Description

Among the vascular endothelial cells, hepatic sinusoidal endothelial (HSE) cells are morphologically unique because they have open fenestrations in their cytoplasm and lack basal lamina. This unique structure is assumed to facilitate the exchange and transport of various substances between blood and hepatocytes through the space of Disse. It has been suggested that the formation of this structure is regulated by hepatocyte-related soluble factors or by the extracellular matrix. The antibody was observed no cross-reactivity with other types of endothelial cells or non-endothelial cells. By immunoelectron microscopy, the antigen recognized by the antibody was localized to the membrane surface of HSE. Immunoblot analysis revealed that the antibody recognized a single 45 kDa band. The antibody may be a useful marker to study the role of HSE in various pathophysiological conditions of the liver.