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#10377 Anti-Human RGMa (410-10) Mouse IgG MoAb

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Intended Use：: Research reagents

Application：: WB, IP, FCM

Package Size1：: 100 μg

Package Size2：: 10 μg

Note on Application Abbreviations: WB:Western Blotting; IP:Immunoprecipitation; FCM:Flow Cytometry

※ The product indicated as "Research reagents" in the column Intended Use cannot be used
　 for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
　 enclosed in the product purchased before use.

Product Overview

Product Code	10377
Product Name	Anti-Human RGMa (410-10) Mouse IgG MoAb
Intended Use	Research reagents
Application	WB, IP, FCM
Species	Human
Immunizing antigen	Synthetic peptide of a part of Human RGMa (LYERTRDLPGRAAAGL)
Source	Mouse-Mouse hybridoma　(X63 - Ag 8.653 × BALB/c mouse spleen cells, supernatant)
Clone Name	410-10
Subclass	IgG2b
Purification Method	Affinity purified with Protein A
Package Form	Lyophilized product from 1 % BSA in PBS containing 0.05 % NaN3
Storage Condition	2 - 8℃
Poisonous and Deleterious Substances	Applicable
Cartagena	Not Applicable
Package Size 1	100 μg
Package Size 2	10 μg
Remarks1	The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission.

Product Description

RGMa (Repulsive Guidance Molecule a) is a GIP-anchored protein, about 33 kDa, and it is implicated in axonal guidance and neural tube closure of embryonic retina. It has reported as a potent inhibitor of axonal regeneration in the adult central nervous system (CNS). It is speculated that RGMa inhibits neurite outgrowth by activating the RhoA-Rho kinase signaling pathway in vitro. While, it has reported that, in a rat SCI (spinal cord injury) model, neurite outgrowth is enhanced by administration of anti-RGMa antibody to lesion site, resulting they are improved in mortor functional recovery. Thus function analysis of RGMa is attracting attention in a research field of axonal regeneration of CNS. This antibody detects human RGMa and can be used for western blotting, immuno-precipitation and FACS analysis.