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#18256 Anti-Rat GRO/CINC-1 (C) Rabbit IgG Affinity Purify

Intended Use:
Research reagents
Application:
WB, NT
Package Size1:
100 μg
Note on Application Abbreviations
WB:Western Blotting
NT:Neutralization Test

※ The product indicated as "Research reagents" in the column Intended Use cannot be used
  for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
  enclosed in the product purchased before use.

Product Overview

Product Overview

Product Code 18256
Product Name Anti-Rat GRO/CINC-1 (C) Rabbit IgG Affinity Purify
Intended Use Research reagents
Application WB, NT
Species Rat
Immunizing antigen Synthetic peptides of the C-terminal part of rat GRO/CINC-1
Purification Method Purified with antigen peptide
Specificity Not cross-react with rat GRO/CINC-2α, -2β, -3.
Package Form Lyophilized product in PBS
Storage Condition 2 - 8℃
Poisonous and Deleterious Substances Not Applicable
Cartagena Not Applicable
Package Size 1 100 μg
Remarks1 The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission.

Product Description

Product Description

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The sale of this product will be ended when all the stock is sold out.
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GRO (Growth Related Oncogene) belonging to IL-8 family is polypeptide which has three isoforms α, β and γ, and it inhibits proliferation of endothelial cells. GRO/CINC-1 (cytokine-induced neutrophil chemo attractant 1) was originally purified from media conditioned by IL-1β stimulated rat kidney epithelioid cells (NRK-52E.) Amino acid sequence that encodes rat CINC-1 was identified in 1989 by Watanabe’s group at Toyama Medical and Pharmaceutical University. CINC-1 is a member of the alpha (CXC) subfamily of chemokines. Three additional rat CXC chemokines (CINC-2α, CINC-2β, CINC-3/MIP-2) have been identified. The protein sequence of CINC-1 is 63 - 67% identical to that of CINC-2α, CINC-2β and CINC-3/MIP-2. In addition, each of GROα, GROβ and GROγ is sharing 68%, 71% and 69% identity with CINC-1. This has been suggested that CINCs are the rat counterparts of human GROs. GROα/MGSA has a high homology with IL-8 in amino acid sequences. It has been reported that it also has a similar configuration in 3D structural analysis and the almost same level of leukocyte chemotaxis with IL-8. Also its production from activated monocyte, fibroblast, epithelial and endothelial cells has been reported. It has been reported that GROβ inhibits angiogenesis in case of administration of GRO in vivo. Mouse KC (Keratinocyto-derived Cytokine) is a counterpart of human GRO protein and it has been reported that KC is produced in such as activated monocyte and fibroblast. Mouse MIP (Macrophage Inflammatory Protein) is polypeptide which has leukocyte chemotaxis and it originally was discovered as a small protein (molecular weight about 8 kDa) induced by the lipo-polysaccharide stimulation in the macrophage cell line. Two kinds, MIP-1 and MIP-2 are identified by the research afterwards.

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