#18761 Anti-Human Sir2/SIRT1 Rabbit IgG Affinity Purify

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Intended Use：: Research reagents

Application：: WB, IP, IHC

Package Size1：: 100 μg

Package Size2：: 10 μg

Note on Application Abbreviations: WB:Western Blotting; IP:Immunoprecipitation; IHC:Immunohistochemistry

※ The product indicated as "Research reagents" in the column Intended Use cannot be used
　 for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
　 enclosed in the product purchased before use.

Product Overview

Product Code	18761
Product Name	Anti-Human Sir2/SIRT1 Rabbit IgG Affinity Purify
Intended Use	Research reagents
Application	WB, IP, IHC
Species	Human
Immunizing antigen	Synthetic peptides of the part of C-terminal of human Sir2/SIRT1(LEDEPDVPERAGG)
Purification Method	Purified with antigen peptides
Specificity	Confirmed by western blotting
Package Form	Lyophilized product from PBS containing 1 % BSA and 0.05 % NaN3
Storage Condition	2 - 8℃
Poisonous and Deleterious Substances	Applicable
Cartagena	Not Applicable
Package Size 1	100 μg
Package Size 2	10 μg
Remarks1	The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission.

Product Description

Imai et al. have found that S. cerevisiae Sir2p and its higher eukaryotic orthologs are novel nicotinamide adenine dinucleotide (NAD)-dependent histone/protein deacetylases. Sir2 proteins promote longevity in yeast and in C. elegans by silencing rDNA and regulating the insulin/IGF-1 signaling pathway, respectively. The enzymatic activities and functions of Sir2 proteins are highly conserved in evolution. In 2001, Vaziri, H. et al. have found that mammalian Sir2 negatively regulates the p53 function by physically interacting with and deacetylating the protein. This aspect of Sir2 function may connect various cellular damages, such as oxidative stress, to aging and carcinogenesis.