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#18871 Anti-Human DNMT-1 (DNA Methyltransferase-1) Rabbit IgG Affinity Purify

  • WB
Intended Use：
Research reagents
Application：
WB
Package Size1：
100 μg
Package Size2：
10 μg
Note on Application Abbreviations
WB:Western Blotting

※ The product indicated as "Research reagents" in the column Intended Use cannot be used
　 for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
　 enclosed in the product purchased before use.

Product Overview

Product Overview

Product Code 18871
Product Name Anti-Human DNMT-1 (DNA Methyltransferase-1) Rabbit IgG Affinity Purify
Intended Use Research reagents
Application WB
Species Human
Immunizing antigen Synthetic peptide of the C terminal part of Human DNMT-1 (MLAKARESASAKIKE)
Purification Method Purified with antigen peptide
Specificity Confirmed by western blotting using HeLa, SY and HT-29 cells.
Package Form Lyophilized product from 1 % BSA in PBS containing 0.05% NaN3
Storage Condition 2 - 8℃
Poisonous and Deleterious Substances Applicable
Cartagena Not Applicable
Package Size 1 100 μg
Package Size 2 10 μg
Remarks1 The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission.

Product Description

Product Description

The DNMT-1 is one of the enzymes responsible for methylation. Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. It is identified three families of mammalian DNA methyltransferase genes, which include DNMT-1, DNMT-2 and DNMT-3. The DNMT-1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality.
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