#18781 Anti-Human IRF-3 (Interferon Regulatory Factor-3) Rabbit IgG Affinity Purify

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Intended Use：: Research reagents

Application：: WB, IP, IHC

Package Size1：: 100 μg

Package Size2：: 10 μg

Note on Application Abbreviations: WB:Western Blotting; IP:Immunoprecipitation; IHC:Immunohistochemistry

※ The product indicated as "Research reagents" in the column Intended Use cannot be used
　 for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
　 enclosed in the product purchased before use.

Product Overview

Product Code	18781
Product Name	Anti-Human IRF-3 (Interferon Regulatory Factor-3) Rabbit IgG Affinity Purify
Intended Use	Research reagents
Application	WB, IP, IHC
Species	Human
Immunizing antigen	Synthetic peptide for a.a.137 - a.a.150 of Human IRF-3(EDILDELLGNMVLA)
Purification Method	Purified with antigen peptide
Specificity	Confirmed by western blotting.
Package Form	Lyophilized product from 1 % BSA in PBS containing 0.05 % NaN3
Storage Condition	2 - 8℃
Poisonous and Deleterious Substances	Applicable
Cartagena	Not Applicable
Package Size 1	100 μg
Package Size 2	10 μg
Remarks1	The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission.

Product Description

Interferon Regulatory Factor-3 (IRF-3) is the gene coding for a regulatory factor that mediates the action of IL-1, TNFα and LPS. It is reported that IRF-3 controls the production of interferons and chemokines in virus infected cells, by a posttranslational mechanism that involves virus induced phosphorylation, protein dimerization, cytoplasmic to nuclear translocation and stimulation of responsive genes. Furthermore, it is reported that the chemokine RANTES, an important physiological inhibitor of HIV replication, is controlled by IRF-3 activation. IRF-3 is ubiquitously expressed in its inactive form in the cytoplasm. Viral infection induces phosphorylation of the Ser 386 in IRF-3 by IRF-3 kinase (IKK-i/ε, TBK-1). This phosphorylation induces dimerization of IRF-3 and association with the coactivators CBP/p300, and the complex activates the target genes in the nucleus.