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Product News2021/07/08
Biomarkers - Titin N-Fragment (Summer Newsletter 2021)

This summer, Tokyo Olympic/Paralympic will be held in Great Tokyo area, so the highlight of this newsletter is Titin-N Fragment related to muscle damage.

PDF Version of this summer newsletter


Titin
, also known as Connection, is a long elastic protein mainly locates at cross striated muscle. Titin is cleaved and released into blood and urine when muscles are damaged.
Titin-N Fragment is a useful tool in research of sport medicine (muscle damage), ALS, NAFLD, cardiac disease, sarcopenia and frailty etc.



Possibility Non-Invasive Biomarker for ALS
https://pubmed.ncbi.nlm.nih.gov/33737450/ 
The study reported that Urinary Titin N-fragment levels normalized with Cr (titin/Cr) were significantly high in ALS (Amyotrophic Lateral Sclerosis) patients, that were associated with the scores of motor functions ALSFRS-R (r=-0.422, p<0.001), and patients with high Titin N-fragment showed poor prognosis.
Learn More


Titin N Fragment Product Lineup
ELISA Kit:
Human Titin N-Fragment Assay Kit - IBL (#27900)
Mouse Titin N-Fragment Assay Kit – IBL (#27602)  New
*Not available in US due to third party's right.

Antibodies:
Anti-Titin-N (53A1) Mouse IgG MoAb (#10423)
Anti-Titin-N (144A2) Mouse IgG MoAb (#10425)
*These antibodies specifically react to human Titin N-Fragment and can be used in ELISA application.

References List 
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