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#10025 Anti-HumanApoE4 (5B5) Mouse IgG MoAb

  • WB
  • Human brain(Altzheimer's Disease)
Intended Use：
Research reagents
Application：
WB, IHC
Package Size1：
200 μg
Package Size2：
10 μg
Note on Application Abbreviations
WB:Western Blotting
IHC:Immunohistochemistry

※ The product indicated as "Research reagents" in the column Intended Use cannot be used
　 for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
　 enclosed in the product purchased before use.

Product Overview

Product Overview

Product Code 10025
Product Name Anti-HumanApoE4 (5B5) Mouse IgG MoAb
Intended Use Research reagents
Application WB, IHC
Species Human
Immunizing antigen Synthetic peptide of a part of Human ApoE4
Source Mouse-Mouse hybridoma(X63 - Ag 8.653 × BALB/c mouse spleen cells, supernatant)
Clone Name 5B5
Subclass IgG1
Purification Method Affinity purified with antigen peptide
Specificity Human ApoE4 specific, not cross-react with Human ApoE2 and ApoE3.
Package Form Lyophilized product from 1 % BSA in PBS containing 0.05 % NaN3
Storage Condition 2 - 8℃
Poisonous and Deleterious Substances Applicable
Cartagena Not Applicable
Package Size 1 200 μg
Package Size 2 10 μg
Remarks1 The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission.

Product Description

Product Description

Apolipoprotein E (ApoE) is a structural component of very low-density lipoprotein (VLDL) synthesized by the liver and intestinally synthesized chylomicrons. It is also a constituent of a subclass of high-density lipoproteins (HDLs) involved in cholesterol transport activity among cells. One of the most important roles of ApoE is to mediate high affinity binding of chylomicrons and VLDL particles that contain ApoE to the low-density lipoprotein (LDL) receptor. This allows for the specific uptake of these particles by the liver that is necessary for transport preventing the accumulation in plasma of cholesterol rich remnants. There are indications that ApoE is also involved in immune system regulation, nerve regeneration and muscle.

References

References

Note: Retrieve by PMID number in displayed by abstract: http://www.ncbi.nlm.nih.gov

FAQ

FAQ

  • Question
    Q.What region of the protein is recognized?
  • Answer
    A.The antibody recognizes the region contains arginine located at position 112 of amino acid sequences of human ApoE4.
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