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#10351 Anti-Human PDGFRβ (22B1) Mouse IgG MoAb

  • NT
  • WB
  • IP
  • FACS
Intended Use：
Research reagents
Application：
WB, IP, FCM
Package Size1：
100 μg
Package Size2：
10 μg
Note on Application Abbreviations
WB:Western Blotting
IP:Immunoprecipitation
FCM:Flow Cytometry

※ The product indicated as "Research reagents" in the column Intended Use cannot be used
　 for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
　 enclosed in the product purchased before use.

Product Overview

Product Overview

Product Code 10351
Product Name Anti-Human PDGFRβ (22B1) Mouse IgG MoAb
Intended Use Research reagents
Application WB, IP, FCM
Species Human
Immunizing antigen Recombinant protein of extracellular domain of human PDGFRβ
Source Mouse-Mouse hybridoma　(X63 - Ag 8.653 × BALB/c mouse spleen cells, supernatant)
Clone Name 22B1
Subclass IgG1
Purification Method Affinity purified with protein A
Specificity Confirmed by western blotting with TIG-7 cell.
Package Form Lyophilized product from 1 % BSA in PBS containing 0.05 % NaN3
Storage Condition 2 - 8℃
Poisonous and Deleterious Substances Applicable
Cartagena Not Applicable
Package Size 1 100 μg
Package Size 2 10 μg
Remarks1 The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission.

Product Description

Product Description

PDGF, a ligand of PDGFR, has 4 isofoms, A-, B-, C- and D-chains, and forms hetero and/or homo dimers, PDGF-AA, -AB, -BB, -CC, -DD. On the other hand, PDGFR has 2 isoforms, α- and β-chains and forms hetero and/or homo dimers, PDGFR-αα, -αβ and -ββ. PDGF-A and PDGF-C binds specifically to PDGFR-α, PDGF-B binds to PDGFR-α and PDGFR-β, and PDGF-D binds specifically to PDGFR-β. In other words, PDGF-AA and PDGF-CC can activate only PDGF-αα, while PDGF-AB can activate PDGFR-αα and PDGFR-αβ, and PDGF-BB can activate PDGFR-αα, -αβ and -ββ. While, PDGF-DD has been reported to be able to activate PDGFR-αβ as well as PDGFR -ββ. When the receptor is dimerized, tyrosine kinase activity in the intracellular region increases and auto-phosphorylation of the tyrosine residue takes place.
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