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#10373 Anti-Mouse ALK (mAb 16-39) Rat IgG MoAb

Intended Use：
Research reagents
Application：
WB, IP
Package Size1：
100 μg
Note on Application Abbreviations
WB:Western Blotting
IP:Immunoprecipitation

※ The product indicated as "Research reagents" in the column Intended Use cannot be used
　 for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
　 enclosed in the product purchased before use.

Product Overview

Product Overview

Product Code 10373
Product Name Anti-Mouse ALK (mAb 16-39) Rat IgG MoAb
Intended Use Research reagents
Application WB, IP
Species Mouse
Immunizing antigen Recombinant protein of the extracellular domain of mouse ALK
Source Rat-Mouse hybridoma, supernatant
Clone Name mAb 16-39
Subclass IgG2b
Purification Method Affinity purified with Protein G
Specificity Reacts with human and mouse ALK.
Package Form Lyophilized product from 1 % BSA in PBS containing 0.05 % NaN3
Storage Condition 2 - 8℃
Poisonous and Deleterious Substances Applicable
Cartagena Not Applicable
Package Size 1 100 μg
Remarks1 The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission.

Product Description

Product Description

Anaplastic lymphoma kinase (ALK, anaplastic lymphoma kinase) is a receptor type tyrosine kinase, and is found to be expressed in the central and peripheral nervous system at late embryonic stage. Motegi et al. developed an agonist monoclonal antibody against the extracellular domain of ALK. This monoclonal antibody (clone mAb16-39) elicits tyrosine phosphorylation of ALK in human neuroblastoma (SK-N-SH) cells. And it also induces further phosphorylation of signal transfer molecules like IRD-1 (insulin receptor substrate-1) which interact with ALK. Moreover, continuous incubation with this antibody induced the cell-growth and neurite outgrowth of SK-N-SH cells.
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