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- #18128 Anti-Human c-Ret (Long Isoform) Rabbit IgG Affinity Purify
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#18128 Anti-Human c-Ret (Long Isoform) Rabbit IgG Affinity Purify
- Intended Use:
- Research reagents
- Application:
- WB, IP
- Package Size1:
- 200 μg
- Package Size2:
- 10 μg
- Note on Application Abbreviations
- WB:Western Blotting
- IP:Immunoprecipitation
※ The product indicated as "Research reagents" in the column Intended Use cannot be used
for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
enclosed in the product purchased before use.
Product Overview
Product Overview
Product Code | 18128 |
---|---|
Product Name | Anti-Human c-Ret (Long Isoform) Rabbit IgG Affinity Purify |
Intended Use | Research reagents |
Application | WB, IP |
Species | Human |
Immunizing antigen | Synthetic peptide of the C-terminal part of Human c-Ret Long Isoform(ANWMLSPSAAKLMDTFDS) |
Purification Method | Purified with antigen peptide |
Specificity | Long Isoform specific. |
Package Form | Lyophilized product in PBS containing 1 % BSA and 0.05 % NaN3 |
Storage Condition | 2 - 8℃ |
Poisonous and Deleterious Substances | Applicable |
Cartagena | Not Applicable |
Package Size 1 | 200 μg |
Package Size 2 | 10 μg |
Remarks1 | The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission. |
Product Description
Product Description
The ret proto-oncogene products (proto-Ret protein) are expressed as 150kDa and 170kDa glycoproteins in neuroblastoma cells and as 150kDa and 190kDa glycoproteins in leukemia cells. These proteins are produced from a single polypeptide of 120kDa by posttranslational glycosylation. Although expression of the ret proto-oncogene was frequently detected in human tumors such as neuroblastoma, pheochromocytoma and thyroid medullary carcinoma, its physiological function is unknown. It turned out that the extracellular domain of the proto-Ret protein contains a cadherin-related sequence that is known to be important for Ca2+-dependent homophilic binding of cadherins. The homologous sequence found in the proto-Ret protein consists of about 110 amino acids and is tandemly repeated 3 - 4 times in the extracellular domains of all vertebrate cadherins. The sequence of the proto-Ret protein showed 20-30% identity with the member of the cadherin superfamily in the amino acid level. This suggests that possibility that the proto-Ret protein may function as a cell adhesion molecule like cadherins.