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#18128 Anti-Human c-Ret (Long Isoform) Rabbit IgG Affinity Purify

  • WB
Intended Use:
Research reagents
Application:
WB, IP
Package Size1:
200 μg
Package Size2:
10 μg
Note on Application Abbreviations
WB:Western Blotting
IP:Immunoprecipitation

※ The product indicated as "Research reagents" in the column Intended Use cannot be used
  for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
  enclosed in the product purchased before use.

Product Overview

Product Overview

Product Code 18128
Product Name Anti-Human c-Ret (Long Isoform) Rabbit IgG Affinity Purify
Intended Use Research reagents
Application WB, IP
Species Human
Immunizing antigen Synthetic peptide of the C-terminal part of Human c-Ret Long Isoform(ANWMLSPSAAKLMDTFDS)
Purification Method Purified with antigen peptide
Specificity Long Isoform specific.
Package Form Lyophilized product in PBS containing 1 % BSA and 0.05 % NaN3
Storage Condition 2 - 8℃
Poisonous and Deleterious Substances Applicable
Cartagena Not Applicable
Package Size 1 200 μg
Package Size 2 10 μg
Remarks1 The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission.

Product Description

Product Description

The ret proto-oncogene products (proto-Ret protein) are expressed as 150kDa and 170kDa glycoproteins in neuroblastoma cells and as 150kDa and 190kDa glycoproteins in leukemia cells. These proteins are produced from a single polypeptide of 120kDa by posttranslational glycosylation. Although expression of the ret proto-oncogene was frequently detected in human tumors such as neuroblastoma, pheochromocytoma and thyroid medullary carcinoma, its physiological function is unknown. It turned out that the extracellular domain of the proto-Ret protein contains a cadherin-related sequence that is known to be important for Ca2+-dependent homophilic binding of cadherins. The homologous sequence found in the proto-Ret protein consists of about 110 amino acids and is tandemly repeated 3 - 4 times in the extracellular domains of all vertebrate cadherins. The sequence of the proto-Ret protein showed 20-30% identity with the member of the cadherin superfamily in the amino acid level. This suggests that possibility that the proto-Ret protein may function as a cell adhesion molecule like cadherins.