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#18121 Anti-Human c-Ret (R787) Rabbit IgG Affinity Purify

  • WB
Intended Use：
Research reagents
Application：
WB, IHC
Package Size1：
100 μg
Package Size2：
10 μg
Note on Application Abbreviations
WB:Western Blotting
IHC:Immunohistochemistry

※ The product indicated as "Research reagents" in the column Intended Use cannot be used
　 for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
　 enclosed in the product purchased before use.

Product Overview

Product Overview

Product Code 18121
Product Name Anti-Human c-Ret (R787) Rabbit IgG Affinity Purify
Intended Use Research reagents
Application WB, IHC
Species Human
Immunizing antigen Synthetic peptide of the C terminal part of Human c-Ret sort isoform
Purification Method Purified with antigen peptide
Specificity Cross-reacts with mouse and rat.
Package Form Lyophilized product from PBS containing 1 % BSA and 0.05 % NaN3
Storage Condition 2 - 8℃
Poisonous and Deleterious Substances Applicable
Cartagena Not Applicable
Package Size 1 100 μg
Package Size 2 10 μg
Remarks1 The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission.

Product Description

Product Description

The ret proto-oncogene products (c-Ret) are expressed as 150kDa and 170kDaglycoproteins in neuroblastoma cells and as 150kDa and 190kDa glycoproteins in leukemia cells. These proteins are produced from a single polypeptide of 120kDa by posttranslational glycosylation. Although expression of the ret proto-oncogene was frequently detected in human tumors such as neuroblastoma,  pheochromocytoma and thyroid medullary carcinoma, its physiological function is unknown. It turned out that the extracellular domain of the c-Ret contains a cadherin-related sequence that is
known to be important for Ca2+-dependent homophilic binding of cadherins. The homologous sequence found in the c-Ret consists of about 110 amino acids and is tandemly repeated 3 – 4 times in the extracellular domains of all vertebrate cadherins. The sequence of the c-Ret showed 20-30% identity with the member of the cadherin superfamily in the amino acid level. This suggests that possibility that the c-Ret may function as a cell adhesion molecule like cadherins. This antibody specifically recognizes human c-Ret short isoform (RET9/R787).
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