#10415 Anti-Human CD20 (N) (4-6H:2C) Mouse IgG MoAb

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Intended Use：: Research reagents

Application：: WB, IHC

Package Size1：: 100 ug

Package Size2：: 10 ug

Note on Application Abbreviations: WB:Western Blotting; IHC:Immunohistochemistry

※ The product indicated as "Research reagents" in the column Intended Use cannot be used
　 for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
　 enclosed in the product purchased before use.

Product Overview

Product Code	10415
Product Name	Anti-Human CD20 (N) (4-6H:2C) Mouse IgG MoAb
Intended Use	Research reagents
Application	WB, IHC
Species	Human
Immunizing antigen	Synthetic peptide of the N-terminal part of human CD20 (CMQSGPKPLFRRMSS)
Source	Mouse-Mouse hybridoma　(P3U1 × BALB/c mouse spleen cells)
Clone Name	4-6H:2C
Subclass	IgG3
Purification Method	Affinity purified with Protein A
Package Form	Lyophilized product from 1.0 mL of PBS containing 1 % BSA and 0.05 % NaN3
Storage Condition	2 - 8℃
Poisonous and Deleterious Substances	Applicable
Cartagena	Not Applicable
Package Size 1	100 ug
Package Size 2	10 ug
Remarks1	The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission.

Product Description

Rituximab used for treatment of lymphoma is an antibody drug of which target is pan-B cell marker, CD20. It has been reported that the C-terminal region of CD20 undertakes a critical role in a binding to rituximab and the association between C-terminal mutations and rituximab-resistance has been investigated. This antibody was developed as a new monoclonal antibody that recognizes the N-terminal region of CD20 molecule to detect comprehensive CD20 regardless of C-terminal mutations. It is expected to be useful for the detailed examination of CD20 molecules by adding this antibody to reserch of CD20.