#28147 Anti-Human Daple Rabbit IgG Affinity Purify

References (0)
FAQ (0)
Related Materials (0)
Related Products (0)

References (0)
FAQ (0)
Related Materials (0)
Related Products (0)

Intended Use：: Research reagents

Application：: WB, IHC, ICC

Package Size1：: 100 μg

Package Size2：: 10 μg

Note on Application Abbreviations: WB:Western Blotting; IHC:Immunohistochemistry; ICC:Immunocytochemistry

※ The product indicated as "Research reagents" in the column Intended Use cannot be used
　 for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
　 enclosed in the product purchased before use.

Product Overview

Product Code	28147
Product Name	Anti-Human Daple Rabbit IgG Affinity Purify
Maker Name	Immuno-Biological Laboratories Co., Ltd.
Intended Use	Research reagents
Application	WB, IHC, ICC
Species	Human
Immunizing antigen	Synthetic peptide of Daple (EPGGDPQTVWYEYG)
Purification Method	Affinity purified with antigen peptide
Specificity	Cross-react with Human Daple
Package Form	Lyophilized product in PBS containing 1 % BSA and 0.05 % NaN3
Storage Condition	2 - 8℃
Poisonous and Deleterious Substances	Applicable
Cartagena	Not Applicable
Package Size 1	100 μg
Package Size 2	10 μg
Remarks1	The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission.

Product Description

Classical (β-catenin dependent) and non-classical (β-catenin non-dependent) Wnt signal pathway are signal pathways that regulate forming and maintaining of embryonic growth or cell structures of organs and amplifying of cells. It is also involved in various diseases including cancers. Especially, it has been well known that the non-classical Wnt signal pathway regulates polarity determination of tissues and migration of cells. It has been revealed that scaffold molecule “Dishevelled (Dvl)” and low molecular weight GTPase “Rho molecular group (Rac, Rho)” that activates downstream have essential roles in this pathway.

Daple is a molecule that was identified by A. Kikuchi et al, Osaka University and it shows that it has a homological sequence with Girdin or Gipie. It is suggested that Daple binds to Dvl and controls activation of Rac depended on Wnt5a stimulus via its mutual interaction. It was discovered that Daple is essential for cell migration and restructuring of actin structure and its molecular mechanism has also an important role for healing of wound of skin by Daple knockout mouse analysis.