IBL News

Dear Valued Customers,
We hope this newsletter finds you well and you enjoy beautiful autumn seasons! This newsletter focuses on Angiotensinogen which deeply related Hypertension.

1 in 3 adults are suffered hypertension  worldwide. 
The renin-angiotensin aldosterone system (RAAS) is an important pathway in maintaining circulatory homeostasis. 
Abnormal activation of RAAS develops cardiovascular disease, including heart failure, cardiac hypertrophy, hypertension, and atherosclerosis. 
Multiple types of drugs targeting RAAS exist and new drugs such siRNA targeting liver Angiotensinogen are also actively researched.
 
Interesting publications about new drugs development (siRNA targeting Angiotensinogen)

Small Interfering RNA Therapeutics in Hypertension: A Viewpoint on Vasopressor and Vasopressor-Sparing Strategies for Counteracting Blood Pressure Lowering by Angiotensinogen-Targeting Small Interfering RNA. Priyanga Ranasinghe et.al. J Am Heart Assoc. 2022 Oct 18;11(20):e027694. PMID: 36216481

Strong and Sustained Antihypertensive Effect of Small Interfering RNA Targeting Liver Angiotensinogen. Estrellita Uijl et.al. 2019 Jun;73(6):1249-1257. PMID: 31030610

 Angiotensinogen (AGT) ELISA kit 

Angiotensinogen (AGT) is a useful biomarker for research in hypertension as it is involved in the Renin-Angiotensin-Aldosterone System (RAAS).
The ratio of des AI AGT / Intact AGT is much stabile renin activity biomarker. The ratio can be calculated through the measurement of both Intact AGT and total AGT in blood.

 Total AGT ELISA Kit 
#27412 Human Total AGT
#27103 Mouse Total AGT
#27104 Rat Total AGT
Detect BOTH Intact (Full Length) and Des AI AGT

 Intact (Full Length) ELISA Kit 
#27742 Human Intact AGT
#27105 Mouse Intact AGT
#27106 Rat Intact AGT
Detect ONLY Intact AGT

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Sales Department
Antibody related Business Division
Immuno-Biological Laboratories Co., Ltd.
Email: do-ibl@ibl-japan.co.jp

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