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#10501 Anti- PP (Pancreatic Polypeptide) (23-2D3) Mouse IgG MoAb

  • IFS staining in PP cells of the islets of Langerhans
  • DAB staining in PP cells of the islets of Langerhans
Intended Use:
Research reagents
Application:
IHC
Package Size1:
50 μg
Package Size2:
5 μg
Note on Application Abbreviations
IHC:Immunohistochemistry

※ The product indicated as "Research reagents" in the column Intended Use cannot be used
  for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
  enclosed in the product purchased before use.

Product Overview

Product Code 10501
Product Name Anti- PP (Pancreatic Polypeptide) (23-2D3) Mouse IgG MoAb
Maker Name Immuno-Biological Laboratories Co., Ltd.
Intended Use Research reagents
Application IHC
Species Human, Mouse, Rat
Immunizing antigen Synthetic peptide for Mouse PP
Source Mouse-Mouse hybridoma (SP2/0-Ag14 ×PPYcre/cre mouse spleen cells)
Clone Name 23-2D3
Subclass IgG1
Purification Method Affinity purified with ProteinG
Specificity Human,Mouse and Rat PP specific.
Does not cross react with Neuropeptide Y(NPY) nor Peptide YY(PYY).
Package Form Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
Storage Condition 2 - 8 ℃
Poisonous and Deleterious Substances Applicable
Cartagena Not Applicable
Package Size 1 50 μg
Package Size 2 5 μg
Remarks1 The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission.

Product Description

Pancreatic Polypeptide (PP) is 36 amino acid polypeptide that is secreted by PP
cells (F cells or γ cells) of the islets of Langerhans of pancreas and it is classified
as NPY family peptide along with Peptide YY (PYY) and Neuropeptide Y (NPY).
The receptors of these NPY family consist of 5 subtypes such as Y1, Y2, Y4, Y5
and Y6 and PP has especially high affinity with Y4 receptor and it has been known
as a satiety factor that suppress appetite by acting on Y4 receptor in the
hypothalamus.
Recently, it has been reported that PP possibly acts as a blood glucose control
factor that suppress the secretion of glucagon by acting on Y4 receptor of alpha
cells after glucose loading.
It has been also considered that PP is secreted through stimulating of the vagus
nerve after meal and it is involved in the regulation of food intake.
Highly specific antibody is required for PP study since it has been reported that
PP cells produce both PP and PYY and these amino acid sequences have high
homology.
This antibody specifically reacts to PP in Human, Rat and Mouse and it can be
used for Immunohistochemistry (Immunofluorescence staining and DAB staining)
against PP cells of the islets of Langerhans.

References

Note: This product is for research use only. It cannot be used as a diagnostic tool or drug.