#10501 Anti- PP (Pancreatic Polypeptide) (23-2D3) Mouse IgG MoAb

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Intended Use：: Research reagents

Application：: IHC

Package Size1：: 50 μg

Package Size2：: 5 μg

Note on Application Abbreviations: IHC:Immunohistochemistry

※ The product indicated as "Research reagents" in the column Intended Use cannot be used
　 for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
　 enclosed in the product purchased before use.

Product Overview

Product Code	10501
Product Name	Anti- PP (Pancreatic Polypeptide) (23-2D3) Mouse IgG MoAb
Maker Name	Immuno-Biological Laboratories Co., Ltd.
Intended Use	Research reagents
Application	IHC
Species	Human, Mouse, Rat
Immunizing antigen	Synthetic peptide for Mouse PP
Source	Mouse-Mouse hybridoma (SP2/0-Ag14 ×PPYcre/cre mouse spleen cells)
Clone Name	23-2D3
Subclass	IgG1
Purification Method	Affinity purified with ProteinG
Specificity	Human,Mouse and Rat PP specific. Does not cross react with Neuropeptide Y(NPY) nor Peptide YY(PYY).
Package Form	Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
Storage Condition	2 - 8 ℃
Poisonous and Deleterious Substances	Applicable
Cartagena	Not Applicable
Package Size 1	50 μg
Package Size 2	5 μg
Remarks1	The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission.

Product Description

Pancreatic Polypeptide (PP) is 36 amino acid polypeptide that is secreted by PP
cells (F cells or γ cells) of the islets of Langerhans of pancreas and it is classified
as NPY family peptide along with Peptide YY (PYY) and Neuropeptide Y (NPY).
The receptors of these NPY family consist of 5 subtypes such as Y1, Y2, Y4, Y5
and Y6 and PP has especially high affinity with Y4 receptor and it has been known
as a satiety factor that suppress appetite by acting on Y4 receptor in the
hypothalamus.
Recently, it has been reported that PP possibly acts as a blood glucose control
factor that suppress the secretion of glucagon by acting on Y4 receptor of alpha
cells after glucose loading.
It has been also considered that PP is secreted through stimulating of the vagus
nerve after meal and it is involved in the regulation of food intake.
Highly specific antibody is required for PP study since it has been reported that
PP cells produce both PP and PYY and these amino acid sequences have high
homology.
This antibody specifically reacts to PP in Human, Rat and Mouse and it can be
used for Immunohistochemistry (Immunofluorescence staining and DAB staining)
against PP cells of the islets of Langerhans.